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c-Mer Tyrosine Kinase MeSH Descriptor Data 2022


MeSH Heading
c-Mer Tyrosine Kinase
Tree Number(s)
D08.811.913.696.620.682.725.400.003
D12.776.476.568.400.003
D12.776.543.750.630.003
D12.776.624.664.700.037
Unique ID
D000076202
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076202
Scope Note
A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling.
Entry Term(s)
MERTK
c-Mer Proto-Oncogene Tyrosine Kinase
Registry Number
EC 2.7.10.1
Previous Indexing
Proto-Oncogene Proteins (1999-2017)
Receptor Protein-Tyrosine Kinases (1999-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2021/05/20
c-Mer Tyrosine Kinase Preferred
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