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Anaplastic Lymphoma Kinase MeSH Descriptor Data 2022


MeSH Heading
Anaplastic Lymphoma Kinase
Tree Number(s)
D08.811.913.696.620.682.725.400.002
D12.776.476.568.400.002
D12.776.543.750.630.002
Unique ID
D000077548
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077548
Scope Note
A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.
Entry Term(s)
ALK Kinase
ALK Tyrosine Kinase Receptor
Anaplastic Lymphoma Receptor Tyrosine Kinase
CD246 Antigen
NPM-ALK
Nucleophosmin-Anaplastic Lymphoma Kinase
Registry Number
EC 2.7.10.1
Public MeSH Note
2019; ANAPLASTIC LYMPHOMA KINASE was indexed under RECEPTOR PROTEIN-TYROSINE KINASES 2012-2018; and under PROTEIN-TYROSINE KINASES 1994-2011
History Note
2019 (1994)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2021/05/20
Anaplastic Lymphoma Kinase Preferred
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