MeSH Browser

MeSH Heading: Receptor, trkA
Tree Number(s): D08.811.913.696.620.682.725.400.660; D12.776.476.568.400.660; D12.776.543.750.630.496; D12.776.543.750.750.400.550.550
Unique ID: D020917
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020917
Scope Note: A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
Entry Version: RECEPT TRKA
Entry Term(s): NTRK1 Receptor; Neurotrophic Tyrosine Kinase Receptor Type 1; Proto-Oncogene Products c-trk; Proto-Oncogene Protein trk; Receptor, Neurotrophic Tyrosine Kinase Type 1; c-trk Protein; gp140 c-trk; gp140(c-TRK); p140-trkA; trk Proto-Oncogene Protein; trk1 Transforming Tryrosine Kinase; trkA Receptor
Previous Indexing: Proto-Oncogene Proteins (1990-1999); Receptor Protein-Tyrosine Kinases (1994-1999); Receptors, Nerve Growth Factor (1994-1999)
Public MeSH Note: 2000; PROTO-ONCOGENE PROTEIN TRK (now RECEPTOR, TYPE 1 NEUROTROPHIC TYROSINE KINASE) was indexed under PROTO-ONCOGENE PROTEINS 1990-1999, RECEPTOR PROTEIN-TYROSINE KINASE 1994-1999 & RECEPTORS, NERVE GROWTH FACTOR 1994-1999
History Note: 2000; use RECEPTOR, TYPE 1 NEUROTROPHIC TYROSINE KINASE(NM) 1990-1999
Date Established: 2000/01/01
Date of Entry: 1999/11/04
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        Anaplastic Lymphoma Kinase [D08.811.913.696.620.682.725.400.002]
        
        c-Mer Tyrosine Kinase [D08.811.913.696.620.682.725.400.003]
        
        Discoidin Domain Receptors [D08.811.913.696.620.682.725.400.005]
        
        ErbB Receptors [D08.811.913.696.620.682.725.400.009]
        
        fms-Like Tyrosine Kinase 3 [D08.811.913.696.620.682.725.400.020]
        
        Proto-Oncogene Proteins c-kit [D08.811.913.696.620.682.725.400.050]
        
        Proto-Oncogene Proteins c-met [D08.811.913.696.620.682.725.400.075]
        
        Proto-Oncogene Proteins c-ret [D08.811.913.696.620.682.725.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D08.811.913.696.620.682.725.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D08.811.913.696.620.682.725.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D08.811.913.696.620.682.725.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D08.811.913.696.620.682.725.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D08.811.913.696.620.682.725.400.180]
        
        Receptor, IGF Type 1 [D08.811.913.696.620.682.725.400.185]
        
        Receptor, Insulin [D08.811.913.696.620.682.725.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D08.811.913.696.620.682.725.400.500]
        
        Receptor, trkA [D08.811.913.696.620.682.725.400.660]
        
        Receptor, trkB [D08.811.913.696.620.682.725.400.700]
        
        Receptor, trkC [D08.811.913.696.620.682.725.400.800]
        
        Receptors, Eph Family [D08.811.913.696.620.682.725.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D08.811.913.696.620.682.725.400.900]
        
        Receptors, TIE [D08.811.913.696.620.682.725.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D08.811.913.696.620.682.725.400.950]
        
        Axl Receptor Tyrosine Kinase [D08.811.913.696.620.682.725.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - Receptor Protein-Tyrosine Kinases [D12.776.476.568.400]
        
        Anaplastic Lymphoma Kinase [D12.776.476.568.400.002]
        
        c-Mer Tyrosine Kinase [D12.776.476.568.400.003]
        
        Discoidin Domain Receptors [D12.776.476.568.400.005]
        
        ErbB Receptors [D12.776.476.568.400.009]
        
        fms-Like Tyrosine Kinase 3 [D12.776.476.568.400.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.476.568.400.050]
        
        Proto-Oncogene Proteins c-met [D12.776.476.568.400.075]
        
        Proto-Oncogene Proteins c-ret [D12.776.476.568.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.476.568.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.476.568.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.476.568.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.476.568.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.476.568.400.180]
        
        Receptor, IGF Type 1 [D12.776.476.568.400.185]
        
        Receptor, Insulin [D12.776.476.568.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.476.568.400.500]
        
        Receptor, trkA [D12.776.476.568.400.660]
        
        Receptor, trkB [D12.776.476.568.400.700]
        
        Receptor, trkC [D12.776.476.568.400.800]
        
        Receptors, Eph Family [D12.776.476.568.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.476.568.400.900]
        
        Receptors, TIE [D12.776.476.568.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.476.568.400.950]
        
        Axl Receptor Tyrosine Kinase [D12.776.476.568.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
        
        Anaplastic Lymphoma Kinase [D12.776.543.750.630.002]
        
        c-Mer Tyrosine Kinase [D12.776.543.750.630.003]
        
        Discoidin Domain Receptors [D12.776.543.750.630.005]
        
        ErbB Receptors [D12.776.543.750.630.009]
        
        fms-Like Tyrosine Kinase 3 [D12.776.543.750.630.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.543.750.630.124]
        
        Proto-Oncogene Proteins c-met [D12.776.543.750.630.186]
        
        Proto-Oncogene Proteins c-ret [D12.776.543.750.630.217]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.543.750.630.233]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.543.750.630.440]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.543.750.630.441]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.543.750.630.442]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.543.750.630.443]
        
        Receptor, IGF Type 1 [D12.776.543.750.630.468]
        
        Receptor, Insulin [D12.776.543.750.630.484]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.630.492]
        
        Receptor, trkA [D12.776.543.750.630.496]
        
        Receptor, trkB [D12.776.543.750.630.498]
        
        Receptor, trkC [D12.776.543.750.630.499]
        
        Receptors, Eph Family [D12.776.543.750.630.500]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.543.750.630.625]
        
        Receptors, TIE [D12.776.543.750.630.687]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.630.750]
        
        Axl Receptor Tyrosine Kinase [D12.776.543.750.630.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Peptide [D12.776.543.750.750]
        
        Receptors, Growth Factor [D12.776.543.750.750.400]
        
        Receptors, Nerve Growth Factor [D12.776.543.750.750.400.550]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.543.750.750.400.550.124]
        
        Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400.550.250]
        
        Receptor, Nerve Growth Factor [D12.776.543.750.750.400.550.500]
        
        Receptor, trkA [D12.776.543.750.750.400.550.550]
        
        Receptor, trkB [D12.776.543.750.750.400.550.600]
        
        Receptor, trkC [D12.776.543.750.750.400.550.700]

Receptor, trkA Preferred

Concept UI: M0328268
Scope Note: A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
Terms: Receptor, trkA Preferred Term
Term UI T358268
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Proto-Oncogene Products c-trk
Term UI T363464
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Proto-Oncogene Protein trk
Term UI T202795
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); gp140(c-TRK)
Term UI T363452
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); trk Proto-Oncogene Protein
Term UI T363453
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); NTRK1 Receptor
Term UI T363457
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Receptor, Neurotrophic Tyrosine Kinase Type 1
Term UI T363458
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); c-trk Protein
Term UI T363459
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); gp140 c-trk
Term UI T363460
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); p140-trkA
Term UI T363461
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); trk1 Transforming Tryrosine Kinase
Term UI T363462
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Neurotrophic Tyrosine Kinase Receptor Type 1
Term UI T363463
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); trkA Receptor
Term UI T202793
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000)

Receptor, trkA MeSH Descriptor Data 2024