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Receptor, trkA MeSH Descriptor Data 2022


MeSH Heading
Receptor, trkA
Tree Number(s)
D08.811.913.696.620.682.725.400.660
D12.776.476.568.400.660
D12.776.543.750.630.496
D12.776.543.750.750.400.550.550
Unique ID
D020917
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020917
Scope Note
A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
Entry Version
RECEPT TRKA
Entry Term(s)
NTRK1 Receptor
Neurotrophic Tyrosine Kinase Receptor Type 1
Proto-Oncogene Products c-trk
Proto-Oncogene Protein trk
Receptor, Neurotrophic Tyrosine Kinase Type 1
c-trk Protein
gp140 c-trk
gp140(c-TRK)
p140-trkA
trk Proto-Oncogene Protein
trk1 Transforming Tryrosine Kinase
trkA Receptor
Registry Number
EC 2.7.10.1
Previous Indexing
Proto-Oncogene Proteins (1990-1999)
Receptor Protein-Tyrosine Kinases (1994-1999)
Receptors, Nerve Growth Factor (1994-1999)
Public MeSH Note
2000; PROTO-ONCOGENE PROTEIN TRK (now RECEPTOR, TYPE 1 NEUROTROPHIC TYROSINE KINASE) was indexed under PROTO-ONCOGENE PROTEINS 1990-1999, RECEPTOR PROTEIN-TYROSINE KINASE 1994-1999 & RECEPTORS, NERVE GROWTH FACTOR 1994-1999
History Note
2000; use RECEPTOR, TYPE 1 NEUROTROPHIC TYROSINE KINASE(NM) 1990-1999
Date Established
2000/01/01
Date of Entry
1999/11/04
Revision Date
2021/05/21
Receptor, trkA Preferred
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