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Pre-B-Cell Leukemia Transcription Factor 1 MeSH Descriptor Data 2022


MeSH Heading
Pre-B-Cell Leukemia Transcription Factor 1
Tree Number(s)
D12.776.260.400.836
D12.776.624.664.700.163
D12.776.930.712
Unique ID
D000075062
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000075062
Scope Note
A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.
Entry Term(s)
PBX1 Homeobox Protein
Pre-B-Cell Leukemia Homeobox 1 Protein
Registry Number
0
Previous Indexing
DNA-Binding Proteins (1993-2017)
Proto-Oncogene Proteins (1993-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/05/22
Pre-B-Cell Leukemia Transcription Factor 1 Preferred
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