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AIRE Protein MeSH Descriptor Data 2024


MeSH Heading
AIRE Protein
Tree Number(s)
D12.776.930.123
Unique ID
D000096927
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000096927
Scope Note
A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY.
Entry Term(s)
APECED Protein
Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein
Autoimmune Regulator Protein
Public MeSH Note
2024; AIRE PROTEIN was indexed under TRANSCRIPTION FACTORS 1997-2023
History Note
2024 (1997)
Date Established
2024/01/01
Date of Entry
2023/07/26
Revision Date
2023/05/16
AIRE Protein Preferred
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