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STAT Transcription Factors MeSH Descriptor Data 2022


MeSH Heading
STAT Transcription Factors
Tree Number(s)
D12.644.360.024.342
D12.776.157.057.186
D12.776.476.024.430
D12.776.930.840
Unique ID
D050791
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D050791
Annotation
general; prefer specifics
Scope Note
A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.
Entry Term(s)
STAT (Signal Transducers and Activators of Transcription) Proteins
Registry Number
0
Public MeSH Note
2006
History Note
2006
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2016/02/18
STAT Transcription Factors Preferred
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