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src Homology Domains MeSH Descriptor Data 2022


MeSH Heading
src Homology Domains
Tree Number(s)
G02.111.570.820.709.275.750.500.750
Unique ID
D018909
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018909
Scope Note
Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
Entry Version
SRC HOMOL DOMAINS
Entry Term(s)
SH Domains
SH1 Domain
SH2 Domain
SH3 Domain
src Homology Region 2 Domain
Previous Indexing
Amino Acid Sequence (1989-1995)
Sequence Homology, Amino Acid (1993-1995)
Public MeSH Note
96
History Note
96
Date Established
1996/01/01
Date of Entry
1995/01/06
Revision Date
2016/05/31
src Homology Domains Preferred
SH2 Domain Narrower
SH3 Domain Narrower
SH1 Domain Narrower
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