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GRB2 Adaptor Protein MeSH Descriptor Data 2022


MeSH Heading
GRB2 Adaptor Protein
Tree Number(s)
D12.644.360.024.290
D12.776.157.057.041
D12.776.476.024.377
Unique ID
D051380
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051380
Scope Note
A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
Entry Term(s)
Abundant Src Homology Protein
GRB2 Adaptor Protein, Grb3-3 Isoform
Grb3-3 Adaptor Protein
Growth Factor Receptor-Bound Protein-2
Registry Number
0
Public MeSH Note
2006; GROWTH FACTOR RECEPTOR-BOUND PROTEIN-2 was indexed under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2005, & under PROTEINS 1992-2004
History Note
2006(1992)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2017/05/24
GRB2 Adaptor Protein Preferred
GRB2 Adaptor Protein, Grb3-3 Isoform Narrower
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