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Paxillin
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Paxillin
Tree Number(s)
D12.644.360.024.316
D12.776.157.057.092
D12.776.476.024.397
D12.776.512.374
D12.776.744.665
Unique ID
D051419
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051419
Scope Note
Paxillin is a signal transducing adaptor protein that localizes to
FOCAL ADHESIONS
via its four LIM domains. It undergoes
PHOSPHORYLATION
in response to integrin-mediated
CELL ADHESION
, and interacts with a variety of proteins including
VINCULIN
;
FOCAL ADHESION KINASE
;
PROTO-ONCOGENE PROTEIN PP60(C-SRC
); and
PROTO-ONCOGENE PROTEIN C-CRK
.
Registry Numbers
0
Public MeSH Note
2006; PAXILLIN was indexed under CYTOSKELETAL PROTEINS & PHOSPHOPROTEINS 1991-2005
History Note
2006(1991)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2016/03/30
Allowable Qualifiers
administration & dosage (AD)
adverse effects (AE)
agonists (AG)
analysis (AN)
antagonists & inhibitors (AI)
biosynthesis (BI)
blood (BL)
cerebrospinal fluid (CF)
chemical synthesis (CS)
chemistry (CH)
classification (CL)
deficiency (DF)
drug effects (DE)
economics (EC)
genetics (GE)
history (HI)
immunology (IM)
isolation & purification (IP)
metabolism (ME)
pharmacokinetics (PK)
pharmacology (PD)
physiology (PH)
poisoning (PO)
radiation effects (RE)
standards (ST)
supply & distribution (SD)
therapeutic use (TU)
toxicity (TO)
ultrastructure (UL)
urine (UR)
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
14-3-3 Proteins [D12.644.360.024.050]
A Kinase Anchor Proteins [D12.644.360.024.065]
Angiomotins [D12.644.360.024.082]
Arrestins [D12.644.360.024.098]
CARD Signaling Adaptor Proteins [D12.644.360.024.131]
Caveolin 1 [D12.644.360.024.264]
Caveolin 2 [D12.644.360.024.272]
Cortactin [D12.644.360.024.280]
Crk-Associated Substrate Protein [D12.644.360.024.282]
Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.024.285]
Discs Large Homolog 1 Protein [D12.644.360.024.287]
Dishevelled Proteins [D12.644.360.024.288]
GRB2 Adaptor Protein [D12.644.360.024.290]
GRB7 Adaptor Protein [D12.644.360.024.299]
GRB10 Adaptor Protein [D12.644.360.024.300]
Insulin Receptor Substrate Proteins [D12.644.360.024.301]
Interferon Regulatory Factors [D12.644.360.024.302]
Interferon-Stimulated Gene Factor 3 [D12.644.360.024.303]
Kelch-Like ECH-Associated Protein 1 [D12.644.360.024.306]
Mediator Complex [D12.644.360.024.309]
mTOR Associated Protein, LST8 Homolog [D12.644.360.024.310]
Myeloid Differentiation Factor 88 [D12.644.360.024.311]
Nod Signaling Adaptor Proteins [D12.644.360.024.313]
Nuclear Receptor Coactivators [D12.644.360.024.314]
Nuclear Receptor Interacting Protein 1 [D12.644.360.024.315]
Paxillin [D12.644.360.024.316]
PII Nitrogen Regulatory Proteins [D12.644.360.024.318]
Protein Inhibitors of Activated STAT [D12.644.360.024.319]
Proto-Oncogene Proteins c-crk [D12.644.360.024.320]
Proto-Oncogene Proteins c-vav [D12.644.360.024.321]
Rabphilin-3A [D12.644.360.024.322]
Rapamycin-Insensitive Companion of mTOR Protein [D12.644.360.024.323]
Regulatory-Associated Protein of mTOR [D12.644.360.024.324]
Retinoblastoma Binding Proteins [D12.644.360.024.328]
Sequestosome-1 Protein [D12.644.360.024.329]
Shc Signaling Adaptor Proteins [D12.644.360.024.330]
Signaling Lymphocytic Activation Molecule Associated Protein [D12.644.360.024.332]
Smad Proteins [D12.644.360.024.334]
STAT Transcription Factors [D12.644.360.024.342]
Suppressor of Cytokine Signaling Proteins [D12.644.360.024.374]
Syntenins [D12.644.360.024.437]
Transcriptional Coactivator with PDZ-Binding Motif Proteins [D12.644.360.024.469]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.644.360.024.500]
YAP-Signaling Proteins [D12.644.360.024.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
5-Lipoxygenase-Activating Proteins [D12.776.157.057.001]
14-3-3 Proteins [D12.776.157.057.002]
A Kinase Anchor Proteins [D12.776.157.057.003]
Arrestins [D12.776.157.057.005]
CARD Signaling Adaptor Proteins [D12.776.157.057.006]
Caveolin 1 [D12.776.157.057.010]
Caveolin 2 [D12.776.157.057.012]
Cortactin [D12.776.157.057.014]
Crk-Associated Substrate Protein [D12.776.157.057.016]
Death Domain Receptor Signaling Adaptor Proteins [D12.776.157.057.018]
Discs Large Homolog 1 Protein [D12.776.157.057.023]
Dishevelled Proteins [D12.776.157.057.028]
GRB10 Adaptor Protein [D12.776.157.057.039]
GRB2 Adaptor Protein [D12.776.157.057.041]
GRB7 Adaptor Protein [D12.776.157.057.043]
Insulin Receptor Substrate Proteins [D12.776.157.057.045]
Interferon Regulatory Factors [D12.776.157.057.050]
Interferon-Stimulated Gene Factor 3 [D12.776.157.057.061]
Kelch-Like ECH-Associated Protein 1 [D12.776.157.057.067]
Mediator Complex [D12.776.157.057.072]
mTOR Associated Protein, LST8 Homolog [D12.776.157.057.073]
Myeloid Differentiation Factor 88 [D12.776.157.057.074]
Nod Signaling Adaptor Proteins [D12.776.157.057.078]
Nuclear Receptor Coactivators [D12.776.157.057.080]
Nuclear Receptor Interacting Protein 1 [D12.776.157.057.086]
Paxillin [D12.776.157.057.092]
PII Nitrogen Regulatory Proteins [D12.776.157.057.110]
Protein Inhibitors of Activated STAT [D12.776.157.057.124]
Proto-Oncogene Proteins c-crk [D12.776.157.057.139]
Proto-Oncogene Proteins c-vav [D12.776.157.057.144]
Rabphilin-3A [D12.776.157.057.150]
Rapamycin-Insensitive Companion of mTOR Protein [D12.776.157.057.155]
Regulatory-Associated Protein of mTOR [D12.776.157.057.157]
Retinoblastoma Binding Proteins [D12.776.157.057.158]
Sequestosome-1 Protein [D12.776.157.057.160]
Shc Signaling Adaptor Proteins [D12.776.157.057.162]
Signaling Lymphocytic Activation Molecule Associated Protein [D12.776.157.057.166]
Smad Proteins [D12.776.157.057.170]
STAT Transcription Factors [D12.776.157.057.186]
Suppressor of Cytokine Signaling Proteins [D12.776.157.057.249]
Syntenins [D12.776.157.057.374]
Transcriptional Coactivator with PDZ-Binding Motif Proteins [D12.776.157.057.437]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.776.157.057.500]
YAP-Signaling Proteins [D12.776.157.057.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
5-Lipoxygenase-Activating Proteins [D12.776.476.024.034]
14-3-3 Proteins [D12.776.476.024.050]
A Kinase Anchor Proteins [D12.776.476.024.069]
Angiomotins [D12.776.476.024.087]
Arrestins [D12.776.476.024.104]
CARD Signaling Adaptor Proteins [D12.776.476.024.139]
Caveolin 1 [D12.776.476.024.280]
Caveolin 2 [D12.776.476.024.295]
Cortactin [D12.776.476.024.311]
Crk-Associated Substrate Protein [D12.776.476.024.316]
Death Domain Receptor Signaling Adaptor Proteins [D12.776.476.024.320]
Discs Large Homolog 1 Protein [D12.776.476.024.325]
Dishevelled Proteins [D12.776.476.024.330]
GRB2 Adaptor Protein [D12.776.476.024.377]
GRB7 Adaptor Protein [D12.776.476.024.379]
GRB10 Adaptor Protein [D12.776.476.024.380]
Homer Scaffolding Proteins [D12.776.476.024.381]
Insulin Receptor Substrate Proteins [D12.776.476.024.382]
Interferon Regulatory Factors [D12.776.476.024.385]
Interferon-Stimulated Gene Factor 3 [D12.776.476.024.386]
Kelch-Like ECH-Associated Protein 1 [D12.776.476.024.387]
Mediator Complex [D12.776.476.024.388]
mTOR Associated Protein, LST8 Homolog [D12.776.476.024.389]
Myeloid Differentiation Factor 88 [D12.776.476.024.390]
Nod Signaling Adaptor Proteins [D12.776.476.024.391]
Nuclear Receptor Coactivators [D12.776.476.024.394]
Nuclear Receptor Interacting Protein 1 [D12.776.476.024.396]
Paxillin [D12.776.476.024.397]
PII Nitrogen Regulatory Proteins [D12.776.476.024.400]
Protein Inhibitors of Activated STAT [D12.776.476.024.402]
Proto-Oncogene Proteins c-crk [D12.776.476.024.404]
Proto-Oncogene Proteins c-vav [D12.776.476.024.407]
Rabphilin-3A [D12.776.476.024.409]
Rapamycin-Insensitive Companion of mTOR Protein [D12.776.476.024.411]
Receptor Activity-Modifying Proteins [D12.776.476.024.414]
Regulatory-Associated Protein of mTOR [D12.776.476.024.419]
Retinoblastoma Binding Proteins [D12.776.476.024.420]
Sequestosome-1 Protein [D12.776.476.024.422]
Shc Signaling Adaptor Proteins [D12.776.476.024.424]
Signaling Lymphocytic Activation Molecule Associated Protein [D12.776.476.024.426]
Smad Proteins [D12.776.476.024.428]
STAT Transcription Factors [D12.776.476.024.430]
Suppressor of Cytokine Signaling Proteins [D12.776.476.024.437]
Syntenins [D12.776.476.024.468]
Transcriptional Coactivator with PDZ-Binding Motif Proteins [D12.776.476.024.484]
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.776.476.024.500]
YAP-Signaling Proteins [D12.776.476.024.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
LIM Domain Proteins [D12.776.512]
Lim Kinases [D12.776.512.124]
LIM-Homeodomain Proteins [D12.776.512.249]
Paxillin [D12.776.512.374]
Zyxin [D12.776.512.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Phosphoproteins [D12.776.744]
bcl-Associated Death Protein [D12.776.744.049]
BRCA1 Protein [D12.776.744.100]
Caseins [D12.776.744.150]
Caveolin 1 [D12.776.744.287]
Caveolin 2 [D12.776.744.356]
CDC2 Protein Kinase [D12.776.744.360]
Cortactin [D12.776.744.390]
Crk-Associated Substrate Protein [D12.776.744.425]
Dopamine and cAMP-Regulated Phosphoprotein 32 [D12.776.744.459]
Fanconi Anemia Complementation Group A Protein [D12.776.744.476]
Fanconi Anemia Complementation Group D2 Protein [D12.776.744.484]
Fanconi Anemia Complementation Group G Protein [D12.776.744.488]
Focal Adhesion Kinase 1 [D12.776.744.493]
Integrin-Binding Sialoprotein [D12.776.744.527]
Interferon Regulatory Factor-3 [D12.776.744.562]
Interferon Regulatory Factor-7 [D12.776.744.631]
Paxillin [D12.776.744.665]
Phosvitin [D12.776.744.700]
Plectin [D12.776.744.736]
Smad Proteins, Receptor-Regulated [D12.776.744.741]
Retinoblastoma-Like Protein p107 [D12.776.744.747]
Retinoblastoma-Like Protein p130 [D12.776.744.755]
Retinoblastoma Protein [D12.776.744.770]
Stathmin [D12.776.744.772]
Synapsins [D12.776.744.840]
Tumor Suppressor Protein p53 [D12.776.744.845]
Vitellogenins [D12.776.744.925]
Zyxin [D12.776.744.962]
Expand All
Collapse All
Paxillin
Preferred
Concept UI
M0193207
Registry Numbers
0
Scope Note
Paxillin is a signal transducing adaptor protein that localizes to
FOCAL ADHESIONS
via its four LIM domains. It undergoes
PHOSPHORYLATION
in response to integrin-mediated
CELL ADHESION
, and interacts with a variety of proteins including
VINCULIN
;
FOCAL ADHESION KINASE
;
PROTO-ONCOGENE PROTEIN PP60(C-SRC
); and
PROTO-ONCOGENE PROTEIN C-CRK
.
Terms
Paxillin
Preferred Term
Term UI
T223212
Date
01/01/1955
LexicalTag
NON
ThesaurusID
NLM (2006)
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