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Focal Adhesion Kinase 1 MeSH Descriptor Data 2022


MeSH Heading
Focal Adhesion Kinase 1
Tree Number(s)
D08.811.913.696.620.682.725.049.500
D12.776.476.568.049.500
D12.776.744.493
Unique ID
D051417
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051417
Scope Note
A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
Entry Term(s)
Endogenous Substrate pp120
Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK
Protein Tyrosine Kinase 2
p125FAK Protein
Registry Number
EC 2.7.10.2
Public MeSH Note
2006; ENDOGENOUS SUBSTRATE PP120, FOCAL ADHESION-ASSOCIATED, PROTEIN-TYROSINE KINASE PP125FAK, & P125FAK PROTEIN were indexed under PROTEIN-TYROSINE KINASE 2001-2005, & under CELL ADHESION MOLECULES 1990-2000, & MEMBRANE GLYCOPROTEINS 1987-1992, MEMBRANE PROTEINS 1986-1987
History Note
2006(1986)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2021/05/21
Focal Adhesion Kinase 1 Preferred
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