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Dishevelled Proteins MeSH Descriptor Data 2023


MeSH Heading
Dishevelled Proteins
Tree Number(s)
D12.644.360.024.288
D12.776.157.057.028
D12.776.476.024.330
Unique ID
D000072261
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000072261
Scope Note
A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.
Entry Term(s)
Dishevelled Protein
Dishevelled-1 Protein
Dishevelled-2 Protein
Dishevelled-3 Protein
Registry Number
0
Public MeSH Note
2017; DISHEVELLED PROTEINS was indexed under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2006-2016; under PHOSPHOPROTEINS 1998-2016; and under PROTEINS 1994-1997
History Note
2017 (1994)
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2017/05/24
Dishevelled Proteins Preferred
Dishevelled-3 Protein Narrower
Dishevelled-1 Protein Narrower
Dishevelled-2 Protein Narrower
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