NLM Logo

Kelch-Like ECH-Associated Protein 1 MeSH Descriptor Data 2022


MeSH Heading
Kelch-Like ECH-Associated Protein 1
Tree Number(s)
D12.644.360.024.306
D12.776.157.057.067
D12.776.476.024.387
Unique ID
D000072019
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000072019
Scope Note
An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.
Entry Term(s)
KEAP-1 Protein
KEAP1 Protein
Registry Number
0
Previous Indexing
Adaptor Proteins, Signal Transducing (2005-2016)
Carrier Proteins (1999-2016)
Intracellular Signaling Peptides and Proteins (2004-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/05/27
Kelch-Like ECH-Associated Protein 1 Preferred
page delivered in 0.156s