MeSH Browser

MeSH Heading: Homer Scaffolding Proteins
Tree Number(s): D12.776.476.024.381
Unique ID: D000072233
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072233
Scope Note: Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1, Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis, whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells. Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signaling. They function as a molecular switch in metabotropic glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.
Entry Term(s): Homer 1; Homer 1 Proteins; Homer 1C; Homer 1C Proteins; Homer 1a; Homer 2; Homer 2 Proteins; Homer 3; Homer 3 Proteins; Homer Protein; Homer Proteins
Public MeSH Note: 2017; HOMER PROTEIN was indexed under NEUROPEPTIDES 1997-2004, and under CARRIER PROTEINS 2005-2016
History Note: 2017 (1997)
Date Established: 2017/01/01
Date of Entry: 2016/07/11
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0274049
Scope Note: Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1, Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis, whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells. Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signaling. They function as a molecular switch in metabotropic glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.
Terms: Homer Scaffolding Proteins Preferred Term
Term UI T000902752
Date06/13/2016
LexicalTag NON
ThesaurusID NLM (2017); Homer Protein
Term UI T001089190
Date09/28/2020
LexicalTag NON
ThesaurusID NLM (2022); Homer Proteins
Term UI T000902747
Date06/13/2016
LexicalTag NON
ThesaurusID NLM (2017)

Homer Scaffolding Proteins MeSH Descriptor Data 2024