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Homer Scaffolding Proteins MeSH Descriptor Data 2022


MeSH Heading
Homer Scaffolding Proteins
Tree Number(s)
D12.776.476.024.381
Unique ID
D000072233
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000072233
Scope Note
Homer proteins belong to a family of adaptor and scaffold proteins which include Homer1, Homer2 and Homer3. Homer1 and Homer2 play a role in the regulation of calcium homeostasis, whereas Homer3 functions in stimulating changes in actin dynamics in neurons and T-cells. Homer proteins are best known as scaffold proteins at the post-synaptic density where they facilitate synaptic signaling. They function as a molecular switch in metabotropic glutamate receptor (MGluR) signaling, and are associated with human Fragile X syndrome.
Entry Term(s)
Homer 1
Homer 1 Proteins
Homer 1C
Homer 1C Proteins
Homer 1a
Homer 2
Homer 2 Proteins
Homer 3
Homer 3 Proteins
Homer Protein
Homer Proteins
Registry Number
0
Public MeSH Note
2017; HOMER PROTEIN was indexed under NEUROPEPTIDES 1997-2004, and under CARRIER PROTEINS 2005-2016
History Note
2017 (1997)
Date Established
2017/01/01
Date of Entry
2016/07/11
Revision Date
2021/06/30
Homer Scaffolding Proteins Preferred
Homer 1C Narrower
Homer 3 Narrower
Homer 2 Narrower
Homer 1 Narrower
Homer 1a Narrower
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