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Sequestosome-1 Protein MeSH Descriptor Data 2022


MeSH Heading
Sequestosome-1 Protein
Tree Number(s)
D12.644.360.024.329
D12.776.094.750
D12.776.157.057.160
D12.776.476.024.422
Unique ID
D000071456
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071456
Scope Note
A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
Entry Term(s)
EBI3-Associated Protein of 60 KDa
EBIAP Protein
Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
Ubiquitin-Binding Protein p62
Registry Number
0
Previous Indexing
Adaptor Proteins, Signal Transducing (1996-2016)
Heat-Shock Proteins (1996-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/04/15
Sequestosome-1 Protein Preferred
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