MeSH Browser

MeSH Heading: Autophagy-Related Protein 12
Tree Number(s): D12.776.094.391; D12.776.947.125
Unique ID: D000071192
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071192
Scope Note: A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization to vesicle membranes.
Entry Term(s): ATG12 Protein; Ubiquitin-Like Protein ATG12
Registry Numbers: 0
Previous Indexing: Small Ubiquitin-Related Modifier Proteins (2008-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/25

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000613485
Registry Numbers: 0
Scope Note: A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization to vesicle membranes.
Terms: Autophagy-Related Protein 12 Preferred Term
Term UI T000893523
Date01/12/2016
LexicalTag NON
ThesaurusID NLM (2017); Ubiquitin-Like Protein ATG12
Term UI T000893524
Date01/12/2016
LexicalTag ABX
ThesaurusID NLM (2017); ATG12 Protein
Term UI T000893525
Date01/12/2016
LexicalTag ABX
ThesaurusID NLM (2017)

Autophagy-Related Protein 12 MeSH Descriptor Data 2024