MeSH Browser

MeSH Heading: NEDD8 Protein
Tree Number(s): D12.776.947.218
Unique ID: D000075687
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075687
Scope Note: A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins
Entry Term(s): NEDD-8 Protein; Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8; Ubiquitin-like Protein NEDD8
Previous Indexing: Ubiquitins (1993-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000631126
Scope Note: A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins
Terms: NEDD8 Protein Preferred Term
Term UI T000923462
Date05/05/2017
LexicalTag ACX
ThesaurusID NLM (2018); NEDD-8 Protein
Term UI T000923463
Date05/05/2017
LexicalTag ACX
ThesaurusID NLM (2018); Ubiquitin-like Protein NEDD8
Term UI T000923464
Date05/05/2017
LexicalTag ACX
ThesaurusID NLM (2018); Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8
Term UI T000923465
Date05/05/2017
LexicalTag NON
ThesaurusID NLM (2018)

NEDD8 Protein MeSH Descriptor Data 2024