MeSH Browser

MeSH Heading: Autophagy-Related Protein 7
Tree Number(s): D12.776.094.399
Unique ID: D000071193
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071193
Scope Note: An autophagy related protein that is similar to UBIQUITIN-ACTIVATING ENZYME E1. It functions in CYTOPLASM to VACUOLE transport (Cvt) and AUTOPHAGY by activating ATG12 PROTEIN for its conjugation with ATG5 PROTEIN, as well as the conjugation of ATG8 FAMILY PROTEINS with phosphatidylethanolamine for ATG8 association to Cvt vesicles and AUTOPHAGOSOME membranes. It is also required for the nitrogen starvation response in yeast, MITOPHAGY; and autophagic cell death induced by CASPASE 8 inhibition.
Entry Term(s): ATG12-Activating Enzyme E1 ATG7; ATG7 Protein; Ubiquitin-Activating Enzyme E1-like Protein; Ubiquitin-Like Modifier-Activating Enzyme ATG7
Registry Numbers: EC 6.2.1.45
Previous Indexing: Microtubule-Associated Proteins (2005-2016); Ubiquitin-Activating Enzymes (2006-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/25

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physiology (PH)

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radiation effects (RE)

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supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Autophagy-Related Protein 7 MeSH Descriptor Data 2025