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Caspase 8 MeSH Descriptor Data 2022


MeSH Heading
Caspase 8
Tree Number(s)
D08.811.277.656.262.500.126.550.800
D08.811.277.656.300.200.126.550.800
D12.776.157.057.018.037
D12.776.476.024.320.025
D12.776.476.075.405.550.800
D12.776.476.075.421.037
Unique ID
D053181
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053181
Scope Note
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Entry Term(s)
CAP4 Protease
Caspase-8
FLICE Protein
MACH Protein
Mch5 Protease
Pro-Caspase-8
Procaspase-8
Registry Number
EC 3.4.22.-
See Also
Autoimmune Lymphoproliferative Syndrome
Public MeSH Note
2007; CASPASE 8 was indexed under CASPASES 1999-2006 & under CYSTEINE PROTEINASES 1997-1998
History Note
2007(2000)
Entry Combination
antagonists & inhibitors:Caspase Inhibitors
deficiency:Alstrom Syndrome
Date Established
2007/01/01
Date of Entry
2006/07/05
Revision Date
2021/06/28
Caspase 8 Preferred
Procaspase-8 Narrower
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