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CASP8 and FADD-Like Apoptosis Regulating Protein MeSH Descriptor Data 2025

MeSH Heading: CASP8 and FADD-Like Apoptosis Regulating Protein
Tree Number(s): D12.644.360.024.285.024; D12.644.360.024.500.024; D12.644.360.075.421.024; D12.776.157.057.018.024; D12.776.476.075.421.024
Unique ID: D053446
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053446
Scope Note: An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain.
Entry Term(s): Casper Protein; FLICE-Inhibitory Protein; FLICE-Inhibitory Protein Long Form; FLICE-Inhibitory Protein Short Form; FLIP (Cellular); FLIP-L; FLIP-L Protein; FLIP-S; FLIP-S Protein
Registry Numbers: 0
Public MeSH Note: 2007; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN was indexed under INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS 2005-2006 & under CARRIER PROTEINS 2005-2006
History Note: 2007(1997)
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.024.285]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.644.360.024.285.024]
        
        CRADD Signaling Adaptor Protein [D12.644.360.024.285.050]
        
        Edar-Associated Death Domain Protein [D12.644.360.024.285.100]
        
        Fas-Associated Death Domain Protein [D12.644.360.024.285.200]
        
        TNF Receptor-Associated Death Domain Protein [D12.644.360.024.285.600]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.644.360.024.500]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.644.360.024.500.024]
        
        CRADD Signaling Adaptor Protein [D12.644.360.024.500.050]
        
        Edar-Associated Death Domain Protein [D12.644.360.024.500.061]
        
        Fas-Associated Death Domain Protein [D12.644.360.024.500.124]
        
        TNF Receptor-Associated Death Domain Protein [D12.644.360.024.500.249]
        
        TNF Receptor-Associated Factor 1 [D12.644.360.024.500.500]
        
        TNF Receptor-Associated Factor 2 [D12.644.360.024.500.750]
        
        TNF Receptor-Associated Factor 3 [D12.644.360.024.500.875]
        
        TNF Receptor-Associated Factor 4 [D12.644.360.024.500.906]
        
        TNF Receptor-Associated Factor 5 [D12.644.360.024.500.937]
        
        TNF Receptor-Associated Factor 6 [D12.644.360.024.500.968]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Apoptosis Regulatory Proteins [D12.644.360.075]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.075.421]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.644.360.075.421.024]
        
        CRADD Signaling Adaptor Protein [D12.644.360.075.421.050]
        
        Edar-Associated Death Domain Protein [D12.644.360.075.421.100]
        
        Fas-Associated Death Domain Protein [D12.644.360.075.421.200]
        
        TNF Receptor-Associated Death Domain Protein [D12.644.360.075.421.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.776.157.057.018]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.776.157.057.018.024]
        
        Caspase 8 [D12.776.157.057.018.037]
        
        CRADD Signaling Adaptor Protein [D12.776.157.057.018.050]
        
        Edar-Associated Death Domain Protein [D12.776.157.057.018.100]
        
        Fas-Associated Death Domain Protein [D12.776.157.057.018.200]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.157.057.018.400]
        
        TNF Receptor-Associated Death Domain Protein [D12.776.157.057.018.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Apoptosis Regulatory Proteins [D12.776.476.075]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.776.476.075.421]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.776.476.075.421.024]
        
        Caspase 8 [D12.776.476.075.421.037]
        
        CRADD Signaling Adaptor Protein [D12.776.476.075.421.050]
        
        Edar-Associated Death Domain Protein [D12.776.476.075.421.100]
        
        Fas-Associated Death Domain Protein [D12.776.476.075.421.200]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.075.421.400]
        
        TNF Receptor-Associated Death Domain Protein [D12.776.476.075.421.600]

CASP8 and FADD-Like Apoptosis Regulating Protein Preferred

Concept UI: M0278135
Registry Numbers: 0
Scope Note: An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain.
Terms: CASP8 and FADD-Like Apoptosis Regulating Protein Preferred Term
Term UI T608959
Date09/10/2004
LexicalTag ABX
ThesaurusID NLM (2007); Casper Protein
Term UI T308133
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); FLIP (Cellular)
Term UI T308140
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); FLICE-Inhibitory Protein
Term UI T608954
Date09/10/2004
LexicalTag ABX
ThesaurusID NLM (2007)

FLICE-Inhibitory Protein Long Form Narrower

FLICE-Inhibitory Protein Short Form Narrower

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