MeSH Browser

MeSH Heading: Fas-Associated Death Domain Protein
Tree Number(s): D12.644.360.024.285.200; D12.644.360.024.500.124; D12.644.360.075.421.200; D12.776.157.057.018.200; D12.776.157.057.500.124; D12.776.476.024.320.550; D12.776.476.024.500.124; D12.776.476.075.421.200
Unique ID: D053200
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053200
Scope Note: A signal-transducing adaptor protein that associates with TNF RECEPTOR complexes. It contains a death effector domain that can interact with death effector domains found on INITIATOR CASPASES such as CASPASE 8 and CASPASE 10. Activation of CASPASES via interaction with this protein plays a role in the signaling cascade that leads to APOPTOSIS.
Entry Term(s): FADD Protein, Fas-Associating; Fas Associated Death Domain Protein; Fas-Associating Protein FADD; Fas-Associating Protein with Death Domain; MORT1 Protein
Public MeSH Note: 2007; FAS-ASSOCIATED DEATH DOMAIN PROTEIN was indexed under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2005 & under CARRIER PROTEINS 1995-2004
History Note: 2007(1995)
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.024.285]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.644.360.024.285.024]
        
        CRADD Signaling Adaptor Protein [D12.644.360.024.285.050]
        
        Edar-Associated Death Domain Protein [D12.644.360.024.285.100]
        
        Fas-Associated Death Domain Protein [D12.644.360.024.285.200]
        
        TNF Receptor-Associated Death Domain Protein [D12.644.360.024.285.600]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.644.360.024.500]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.644.360.024.500.024]
        
        CRADD Signaling Adaptor Protein [D12.644.360.024.500.050]
        
        Edar-Associated Death Domain Protein [D12.644.360.024.500.061]
        
        Fas-Associated Death Domain Protein [D12.644.360.024.500.124]
        
        TNF Receptor-Associated Death Domain Protein [D12.644.360.024.500.249]
        
        TNF Receptor-Associated Factor 1 [D12.644.360.024.500.500]
        
        TNF Receptor-Associated Factor 2 [D12.644.360.024.500.750]
        
        TNF Receptor-Associated Factor 3 [D12.644.360.024.500.875]
        
        TNF Receptor-Associated Factor 4 [D12.644.360.024.500.906]
        
        TNF Receptor-Associated Factor 5 [D12.644.360.024.500.937]
        
        TNF Receptor-Associated Factor 6 [D12.644.360.024.500.968]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Apoptosis Regulatory Proteins [D12.644.360.075]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.075.421]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.644.360.075.421.024]
        
        CRADD Signaling Adaptor Protein [D12.644.360.075.421.050]
        
        Edar-Associated Death Domain Protein [D12.644.360.075.421.100]
        
        Fas-Associated Death Domain Protein [D12.644.360.075.421.200]
        
        TNF Receptor-Associated Death Domain Protein [D12.644.360.075.421.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.776.157.057.018]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.776.157.057.018.024]
        
        Caspase 8 [D12.776.157.057.018.037]
        
        CRADD Signaling Adaptor Protein [D12.776.157.057.018.050]
        
        Edar-Associated Death Domain Protein [D12.776.157.057.018.100]
        
        Fas-Associated Death Domain Protein [D12.776.157.057.018.200]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.157.057.018.400]
        
        TNF Receptor-Associated Death Domain Protein [D12.776.157.057.018.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.776.157.057.500]
        
        CRADD Signaling Adaptor Protein [D12.776.157.057.500.050]
        
        Edar-Associated Death Domain Protein [D12.776.157.057.500.061]
        
        Fas-Associated Death Domain Protein [D12.776.157.057.500.124]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.157.057.500.186]
        
        TNF Receptor-Associated Death Domain Protein [D12.776.157.057.500.249]
        
        TNF Receptor-Associated Factor 1 [D12.776.157.057.500.500]
        
        TNF Receptor-Associated Factor 2 [D12.776.157.057.500.750]
        
        TNF Receptor-Associated Factor 3 [D12.776.157.057.500.875]
        
        TNF Receptor-Associated Factor 4 [D12.776.157.057.500.906]
        
        TNF Receptor-Associated Factor 5 [D12.776.157.057.500.937]
        
        TNF Receptor-Associated Factor 6 [D12.776.157.057.500.968]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.776.476.024.320]
        
        Caspase 8 [D12.776.476.024.320.025]
        
        CRADD Signaling Adaptor Protein [D12.776.476.024.320.050]
        
        Edar-Associated Death Domain Protein [D12.776.476.024.320.100]
        
        Fas-Associated Death Domain Protein [D12.776.476.024.320.550]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.024.320.662]
        
        TNF Receptor-Associated Death Domain Protein [D12.776.476.024.320.775]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins [D12.776.476.024.500]
        
        CRADD Signaling Adaptor Protein [D12.776.476.024.500.050]
        
        Edar-Associated Death Domain Protein [D12.776.476.024.500.061]
        
        Fas-Associated Death Domain Protein [D12.776.476.024.500.124]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.024.500.186]
        
        TNF Receptor-Associated Death Domain Protein [D12.776.476.024.500.249]
        
        TNF Receptor-Associated Factor 1 [D12.776.476.024.500.500]
        
        TNF Receptor-Associated Factor 2 [D12.776.476.024.500.750]
        
        TNF Receptor-Associated Factor 3 [D12.776.476.024.500.875]
        
        TNF Receptor-Associated Factor 4 [D12.776.476.024.500.906]
        
        TNF Receptor-Associated Factor 5 [D12.776.476.024.500.937]
        
        TNF Receptor-Associated Factor 6 [D12.776.476.024.500.968]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Apoptosis Regulatory Proteins [D12.776.476.075]
      - Death Domain Receptor Signaling Adaptor Proteins [D12.776.476.075.421]
        
        CASP8 and FADD-Like Apoptosis Regulating Protein [D12.776.476.075.421.024]
        
        Caspase 8 [D12.776.476.075.421.037]
        
        CRADD Signaling Adaptor Protein [D12.776.476.075.421.050]
        
        Edar-Associated Death Domain Protein [D12.776.476.075.421.100]
        
        Fas-Associated Death Domain Protein [D12.776.476.075.421.200]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.075.421.400]
        
        TNF Receptor-Associated Death Domain Protein [D12.776.476.075.421.600]

Fas-Associated Death Domain Protein Preferred

Concept UI: M0245371
Scope Note: A signal-transducing adaptor protein that associates with TNF RECEPTOR complexes. It contains a death effector domain that can interact with death effector domains found on INITIATOR CASPASES such as CASPASE 8 and CASPASE 10. Activation of CASPASES via interaction with this protein plays a role in the signaling cascade that leads to APOPTOSIS.
Terms: Fas-Associated Death Domain Protein Preferred Term
Term UI T664909
Date01/24/2006
LexicalTag NON
ThesaurusID NLM (2007); FADD Protein, Fas-Associating
Term UI T275372
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); Fas-Associating Protein with Death Domain
Term UI T275373
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); Fas-Associating Protein FADD
Term UI T275375
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); MORT1 Protein
Term UI T275376
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2007); Fas Associated Death Domain Protein
Term UI T659684
Date11/22/2005
LexicalTag ABX
ThesaurusID NLM (2007)

Fas-Associated Death Domain Protein MeSH Descriptor Data 2024