NLM Logo

Caspases, Initiator MeSH Descriptor Data 2023


MeSH Heading
Caspases, Initiator
Tree Number(s)
D08.811.277.656.262.500.126.550
D08.811.277.656.300.200.126.550
D12.776.476.075.405.550
Unique ID
D053471
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053471
Scope Note
A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.
Entry Term(s)
Initiator Caspases
Registry Number
EC 3.4.22.-
Previous Indexing
Caspases (1999-2006)
Cysteine Proteinases (1997-1998)
Public MeSH Note
2007
History Note
2007
Entry Combination
antagonists & inhibitors:Caspase Inhibitors
Date Established
2007/01/01
Date of Entry
2006/07/05
Revision Date
2021/05/21
Caspases, Initiator Preferred
page delivered in 0.174s