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Caspase 2 MeSH Descriptor Data 2022


MeSH Heading
Caspase 2
Tree Number(s)
D08.811.277.656.262.500.126.550.200
D08.811.277.656.300.200.126.550.200
D12.776.476.075.405.550.200
Unique ID
D053143
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053143
Scope Note
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Entry Term(s)
Caspase 2 Subunit p12
Caspase 2 Subunit p13
Caspase 2 Subunit p18
Caspase-2
ICH-1 Protease
Pro-Caspase-2
Procaspase-2
Registry Number
EC 3.4.22.-
Public MeSH Note
2007; CASPASE 2 was indexed under CASPASES 1994-2006
History Note
2007(1994)
Entry Combination
antagonists & inhibitors:Caspase Inhibitors
Date Established
2007/01/01
Date of Entry
2006/07/05
Revision Date
2021/05/21
Caspase 2 Preferred
Procaspase-2 Narrower
Caspase 2 Subunit p18 Narrower
Caspase 2 Subunit p12 Narrower
Caspase 2 Subunit p13 Narrower
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