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Autophagy-Related Protein-1 Homolog MeSH Descriptor Data 2022


MeSH Heading
Autophagy-Related Protein-1 Homolog
Tree Number(s)
D08.811.913.696.620.682.700.108
D12.776.094.438
D12.776.476.563.108
Unique ID
D000071189
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071189
Scope Note
A serine/threonine-protein kinase that functions in AUTOPHAGY in response to starvation. It acts on the PHOSPHATIDYLINOSITOL 3-KINASE complex PIK3C3 to regulate AUTOPHAGOSOME formation. It also functions as both a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) and is activated by AMPK, which it also negatively regulates.
Entry Term(s)
Serine-Threonine Protein Kinase ULK1
ULK1 Protein
Unc-51 Like Autophagy Activating Kinase 1
Unc-51-Like Kinase 1
Registry Number
EC 2.7.11.1
Previous Indexing
Protein-Serine-Threonine Kinases (1998-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2021/05/28
Autophagy-Related Protein-1 Homolog Preferred
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