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Checkpoint Kinase 1 MeSH Descriptor Data 2022


MeSH Heading
Checkpoint Kinase 1
Tree Number(s)
D08.811.913.696.620.682.700.143
D12.776.476.563.143
Unique ID
D000071877
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071877
Scope Note
A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle.
Entry Term(s)
Checkpoint-1 Kinase
Chk1 Kinase
Chk1 Protein Kinase
Registry Number
EC 2.7.11.1
Public MeSH Note
2017; CHECKPOINT KINASE 1 was indexed under PROTEIN KINASES 2004-2016
History Note
2017 (2004)
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2021/05/21
Checkpoint Kinase 1 Preferred
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