- Concept UI
- M0217020
- Registry Numbers
- EC 2.7.11.1
- Scope Note
- A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle.
- Terms
-
Checkpoint Kinase 1
Preferred Term
Term UI
T000897158
Date03/16/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Checkpoint-1 Kinase
Term UI
T000897159
Date03/16/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Chk1 Kinase
Term UI
T000897160
Date03/16/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
Chk1 Protein Kinase
Term UI
T000897161
Date03/16/2016
LexicalTag
NON
ThesaurusID
NLM (2017)