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Ribosomal Protein S6 Kinases MeSH Descriptor Data 2022


MeSH Heading
Ribosomal Protein S6 Kinases
Tree Number(s)
D08.811.913.696.620.682.700.862
D12.776.476.563.862
Unique ID
D019893
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019893
Scope Note
A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases.
Entry Term(s)
Ribosomal Protein S6 Kinase
S6 Kinase
S6-H4 Kinase
Registry Number
EC 2.7.11.1
Previous Indexing
Protein Kinases (1985-1992)
Protein-Serine-Threonine Kinases (1993-1997)
See Also
Coffin-Lowry Syndrome
Ribosomal Protein S6
Public MeSH Note
2003; see RIBOSOMAL PROTEIN S6 KINASE 1998-2002; RIBOSOMAL PROTEIN S6 KINASE was indexed under PROTEIN-SERINE-THREONINE KINASES 1993-1997 & PROTEIN KINASES 1985-1992
History Note
2003(1998); use RIBOSOMAL PROTEIN S6 KINASES (NM) 1985-1997
Date Established
1998/01/01
Date of Entry
1997/06/20
Revision Date
2021/06/10
Ribosomal Protein S6 Kinases Preferred
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