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RNA-Binding Protein FUS MeSH Descriptor Data 2022


MeSH Heading
RNA-Binding Protein FUS
Tree Number(s)
D12.776.157.725.813.750.905
D12.776.624.664.700.915
D12.776.664.962.813.750.902
Unique ID
D034702
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D034702
Scope Note
A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.
Entry Term(s)
FUS Protein
FUS RNA-Binding Protein
Fusion Protein in Myxoid Liposarcoma
POMp75 Protein
TLS Protein
Translocated in Liposarcoma Protein
hnRNP P2
Registry Number
0
Previous Indexing
Ribonucleoproteins (1996-2002)
Public MeSH Note
2003; FUS PROTEIN & HNRNP P2 were indexed under RIBONUCLEOPROTEINS 1996-2002; TLS PROTEIN was indexed under 1993-2002 RIBONUCLEOPROTEINS
History Note
2003; for FUS PROTEIN & HNRNP P2 use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1996-2002; for TLS PROTEIN use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1993-2002;
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2015/04/15
RNA-Binding Protein FUS Preferred
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