- Concept UI
- M000614703
- Registry Numbers
- 0
- Scope Note
- A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.
- Terms
-
N-Myc Proto-Oncogene Protein
Preferred Term
Term UI
T000895431
Date02/17/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
N-Myc Protein
Term UI
T000895432
Date02/17/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
MYCN Protein
Term UI
T000895433
Date02/17/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
NMYC Protein
Term UI
T000895434
Date02/17/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
Class E Basic Helix-Loop-Helix Protein 37
Term UI
T000895435
Date02/17/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
BHLHE37 Protein
Term UI
T000895437
Date02/17/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)