MeSH Browser

MeSH Heading: Transcription Factor 4
Tree Number(s): D12.776.260.108.092.937; D12.776.930.125.500.937
Unique ID: D000073940
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000073940
Scope Note: A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
Entry Term(s): TCF-4 Protein; TCF-4 Transcription Factor; TCF4 Transcription Factor
Previous Indexing: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (2010-2017); Transcription Factors (2008-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000625038
Scope Note: A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
Terms: Transcription Factor 4 Preferred Term
Term UI T000913293
Date12/27/2016
LexicalTag NON
ThesaurusID NLM (2018); TCF-4 Protein
Term UI T000913294
Date12/27/2016
LexicalTag ABX
ThesaurusID NLM (2018); TCF4 Transcription Factor
Term UI T000913295
Date12/27/2016
LexicalTag ABX
ThesaurusID NLM (2018); TCF-4 Transcription Factor
Term UI T000913296
Date12/27/2016
LexicalTag ABX
ThesaurusID NLM (2018)

Transcription Factor 4 MeSH Descriptor Data 2024