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Transcription Factor 4 MeSH Descriptor Data 2023


MeSH Heading
Transcription Factor 4
Tree Number(s)
D12.776.260.108.092.937
D12.776.930.125.500.937
Unique ID
D000073940
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000073940
Scope Note
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
Entry Term(s)
TCF-4 Protein
TCF-4 Transcription Factor
TCF4 Transcription Factor
Registry Number
0
Previous Indexing
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (2010-2017)
Transcription Factors (2008-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/02/27
Transcription Factor 4 Preferred
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