Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Transcription Factor 4 MeSH Descriptor Data 2025


MeSH Heading
Transcription Factor 4
Tree Number(s)
D12.776.260.108.092.937
D12.776.930.125.500.937
Unique ID
D000073940
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000073940
Scope Note
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
Entry Term(s)
TCF-4 Protein
TCF-4 Transcription Factor
TCF4 Transcription Factor
Registry Numbers
0
Previous Indexing
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (2010-2017)
Transcription Factors (2008-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/02/27
Transcription Factor 4 Preferred
page delivered in 0.118s