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Lymphocyte Specific Protein Tyrosine Kinase p56(lck) MeSH Descriptor Data 2022


MeSH Heading
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Tree Number(s)
D08.811.913.696.620.682.725.800.315
D12.776.476.568.800.315
D12.776.624.664.700.128
Unique ID
D019860
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019860
Scope Note
This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.
Entry Term(s)
Protein Tyrosine Kinase p56(lck)
Proto-Oncogene Protein c-lck
Proto-Oncogene Protein lck
lck Kinase
p56 lck
Registry Number
EC 2.7.10.2
Previous Indexing
Protein-Tyrosine Kinase (1988-1995)
src-Family Kinases (1996-1997)
Public MeSH Note
98; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK) was indexed under SRC-FAMILY KINASES 1996-97 & PROTEIN-TYROSINE KINASE 1988-95
History Note
98; use LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK) (NM) 1988-97
Date Established
1998/01/01
Date of Entry
1997/07/02
Revision Date
2021/05/21
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Preferred
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