Interleukin-2 MeSH Descriptor Data 2024

MeSH Heading: Interleukin-2
Tree Number(s): D12.644.276.374.465.021; D12.644.276.374.480.372; D12.776.467.374.465.021; D12.776.467.374.480.372; D23.529.374.465.155; D23.529.374.480.372
Unique ID: D007376
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007376
Scope Note: A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.
Entry Term(s): IL-2; IL2; Interleukin II; Interleukine 2; Lymphocyte Mitogenic Factor; RU 49637; RU-49637; Ro-23-6019; Ro-236019; T-Cell Growth Factor; T-Cell Stimulating Factor; TCGF; Thymocyte Stimulating Factor
Pharm Action: Antineoplastic Agents
Analgesics, Non-Narcotic
Previous Indexing: Mitogens (1973-1977)
See Also: Receptors, Interleukin-2
Public MeSH Note: 1990; see INTERLEUKIN 2 1987-1989, see MITOGENIC FACTORS, LYMPHOCYTE 1983-1986, see LYMPHOKINES 1978-1982; RU 49637 was indexed under INTERLEUKIN-2 1993-2006
History Note: 1990(1978)
Date Established: 1983/01/01
Date of Entry: 1977/03/01
Revision Date: 2015/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Interleukins [D12.644.276.374.465]
        
        Interleukin-1 [D12.644.276.374.465.010]
        
        Interleukin-2 [D12.644.276.374.465.021]
        
        Interleukin-3 [D12.644.276.374.465.032]
        
        Interleukin-4 [D12.644.276.374.465.186]
        
        Interleukin-5 [D12.644.276.374.465.202]
        
        Interleukin-6 [D12.644.276.374.465.224]
        
        Interleukin-7 [D12.644.276.374.465.246]
        
        Interleukin-8 [D12.644.276.374.465.312]
        
        Interleukin-9 [D12.644.276.374.465.377]
        
        Interleukin-10 [D12.644.276.374.465.510]
        
        Interleukin-11 [D12.644.276.374.465.511]
        
        Interleukin-12 [D12.644.276.374.465.512]
        
        Interleukin-13 [D12.644.276.374.465.513]
        
        Interleukin-15 [D12.644.276.374.465.515]
        
        Interleukin-16 [D12.644.276.374.465.516]
        
        Interleukin-17 [D12.644.276.374.465.517]
        
        Interleukin-18 [D12.644.276.374.465.518]
        
        Interleukin-23 [D12.644.276.374.465.759]
        
        Interleukin-27 [D12.644.276.374.465.800]
        
        Interleukin-33 [D12.644.276.374.465.850]
        
        Interleukin-22 [D12.644.276.374.465.925]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Lymphokines [D12.644.276.374.480]
        
        Interleukin-2 [D12.644.276.374.480.372]
        
        Leukocyte Migration-Inhibitory Factors [D12.644.276.374.480.428]
        
        Lymphotoxin-alpha [D12.644.276.374.480.438]
        
        Macrophage-Activating Factors [D12.644.276.374.480.615]
        
        Macrophage Migration-Inhibitory Factors [D12.644.276.374.480.625]
        
        Suppressor Factors, Immunologic [D12.644.276.374.480.700]
        
        Transfer Factor [D12.644.276.374.480.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Interleukins [D12.776.467.374.465]
        
        Interleukin-1 [D12.776.467.374.465.010]
        
        Interleukin-2 [D12.776.467.374.465.021]
        
        Interleukin-3 [D12.776.467.374.465.032]
        
        Interleukin-4 [D12.776.467.374.465.178]
        
        Interleukin-5 [D12.776.467.374.465.186]
        
        Interleukin-6 [D12.776.467.374.465.202]
        
        Interleukin-7 [D12.776.467.374.465.224]
        
        Interleukin-8 [D12.776.467.374.465.246]
        
        Interleukin-9 [D12.776.467.374.465.312]
        
        Interleukin-10 [D12.776.467.374.465.510]
        
        Interleukin-11 [D12.776.467.374.465.511]
        
        Interleukin-12 [D12.776.467.374.465.512]
        
        Interleukin-13 [D12.776.467.374.465.513]
        
        Interleukin-15 [D12.776.467.374.465.515]
        
        Interleukin-16 [D12.776.467.374.465.516]
        
        Interleukin-17 [D12.776.467.374.465.517]
        
        Interleukin-18 [D12.776.467.374.465.518]
        
        Interleukin-23 [D12.776.467.374.465.759]
        
        Interleukin-27 [D12.776.467.374.465.800]
        
        Interleukin-33 [D12.776.467.374.465.850]
        
        Interleukin-22 [D12.776.467.374.465.925]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Lymphokines [D12.776.467.374.480]
        
        Interleukin-2 [D12.776.467.374.480.372]
        
        Leukocyte Migration-Inhibitory Factors [D12.776.467.374.480.428]
        
        Lymphotoxin-alpha [D12.776.467.374.480.438]
        
        Macrophage-Activating Factors [D12.776.467.374.480.615]
        
        Macrophage Migration-Inhibitory Factors [D12.776.467.374.480.625]
        
        Suppressor Factors, Immunologic [D12.776.467.374.480.700]
        
        Transfer Factor [D12.776.467.374.480.750]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Interleukins [D23.529.374.465]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Lymphokines [D23.529.374.480]

Interleukin-2 Preferred

Concept UI: M0011506
Scope Note: A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.
Terms: Interleukin-2 Preferred Term
Term UI T022115
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); IL2
Term UI T022128
Date09/18/1981
LexicalTag ABB
ThesaurusID UNK (19XX); Interleukin II
Term UI T022127
Date09/18/1981
LexicalTag NON
ThesaurusID UNK (19XX); Interleukine 2
Term UI T022124
Date08/07/1981
LexicalTag NON
ThesaurusID UNK (19XX); Lymphocyte Mitogenic Factor
Term UI T022116
Date02/25/1977
LexicalTag NON
ThesaurusID UNK (19XX); T-Cell Growth Factor
Term UI T022119
Date04/30/1982
LexicalTag NON
ThesaurusID UNK (19XX); T-Cell Stimulating Factor
Term UI T022120
Date12/15/1980
LexicalTag NON
ThesaurusID UNK (19XX); TCGF
Term UI T022121
Date04/30/1982
LexicalTag ABB
ThesaurusID UNK (19XX); IL-2
Term UI T022123
Date05/25/1989
LexicalTag ABB
ThesaurusID NLM (1990); Thymocyte Stimulating Factor
Term UI T022122
Date12/15/1980
LexicalTag NON
ThesaurusID UNK (19XX)

RU 49637 Narrower

Ro-23-6019 Narrower

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