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Interleukin-12 MeSH Descriptor Data 2022


MeSH Heading
Interleukin-12
Tree Number(s)
D12.644.276.374.465.512
D12.776.467.374.465.512
D23.529.374.465.512
Unique ID
D018664
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018664
Scope Note
A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
Entry Term(s)
Cytotoxic Lymphocyte Maturation Factor
Edodekin Alfa
IL 12
IL-12
IL-12 p70
IL12
Interleukin 12
Interleukin-12 p70
Natural Killer Cell Stimulatory Factor
Pharm Action
Adjuvants, Immunologic
Angiogenesis Inhibitors
Registry Number
187348-17-0
Previous Indexing
Interleukins (1991-1994)
See Also
Immunity, Cellular
Ustekinumab
Public MeSH Note
1995; INTERLEUKIN 12 was indexed under INTERLEUKINS 1991-1994; INTERLEUKIN-12 P70 was indexed under INTERLEUKIN-12 2003-2006
History Note
1995 (1991)
Date Established
1995/01/01
Date of Entry
1994/04/19
Revision Date
2018/10/10
Interleukin-12 Preferred
Edodekin Alfa Related
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