MeSH Browser

MeSH Heading: RNA-Binding Protein EWS
Tree Number(s): D12.644.360.650; D12.776.157.142.750; D12.776.157.725.500.313.900; D12.776.157.725.813.750.900; D12.776.476.650; D12.776.624.664.700.913; D12.776.664.962.500.313.900; D12.776.664.962.813.750.900
Unique ID: D034802
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D034802
Scope Note: A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA.
Entry Term(s): EWS Protein; EWS Proto-Oncogene Protein; EWS RNA Binding Protein 1; EWSR1 Protein; Ewing Sarcoma Breakpoint Region 1 Protein; Ewing Sarcoma Breakpointregion 1 Protein
Registry Numbers: 0
Previous Indexing: Ribonucleoproteins (1995-2002)
See Also: Zinc Fingers
Public MeSH Note: 2003; EWS PROTEIN was indexed under RIBONUCLEOPROTEINS 1995-2002
History Note: 2003; for EWS PROTEIN use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS 1995-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2023/04/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Calmodulin-Binding Proteins [D12.776.157.142]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - RNA-Binding Proteins [D12.776.157.725]
      - Ribonucleoproteins [D12.776.157.725.500]
        
        Heterogeneous-Nuclear Ribonucleoproteins [D12.776.157.725.500.313]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group A-B [D12.776.157.725.500.313.100]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group C [D12.776.157.725.500.313.200]
        
        Heterogeneous-Nuclear Ribonucleoprotein D [D12.776.157.725.500.313.300]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group F-H [D12.776.157.725.500.313.400]
        
        Heterogeneous-Nuclear Ribonucleoprotein K [D12.776.157.725.500.313.500]
        
        Heterogeneous-Nuclear Ribonucleoprotein L [D12.776.157.725.500.313.600]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group M [D12.776.157.725.500.313.700]
        
        Heterogeneous-Nuclear Ribonucleoprotein U [D12.776.157.725.500.313.800]
        
        RNA-Binding Protein EWS [D12.776.157.725.500.313.900]
        
        RNA-Binding Protein FUS [D12.776.157.725.500.313.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - RNA-Binding Proteins [D12.776.157.725]
      - RNA Recognition Motif Proteins [D12.776.157.725.813]
        
        Heterogeneous-Nuclear Ribonucleoproteins [D12.776.157.725.813.750]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group A-B [D12.776.157.725.813.750.100]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group C [D12.776.157.725.813.750.200]
        
        Heterogeneous-Nuclear Ribonucleoprotein D [D12.776.157.725.813.750.300]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group F-H [D12.776.157.725.813.750.400]
        
        Heterogeneous-Nuclear Ribonucleoprotein K [D12.776.157.725.813.750.500]
        
        Heterogeneous-Nuclear Ribonucleoprotein L [D12.776.157.725.813.750.600]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group M [D12.776.157.725.813.750.700]
        
        Heterogeneous-Nuclear Ribonucleoprotein U [D12.776.157.725.813.750.800]
        
        RNA-Binding Protein EWS [D12.776.157.725.813.750.900]
        
        RNA-Binding Protein FUS [D12.776.157.725.813.750.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Oncogene Proteins [D12.776.624.664]
      - Proto-Oncogene Proteins [D12.776.624.664.700]
        
        Axl Receptor Tyrosine Kinase [D12.776.624.664.700.013]
        
        Bcl-2-Like Protein 11 [D12.776.624.664.700.025]
        
        c-Mer Tyrosine Kinase [D12.776.624.664.700.037]
        
        Chemokine CXCL1 [D12.776.624.664.700.049]
        
        Cyclin D1 [D12.776.624.664.700.100]
        
        Fibroblast Growth Factor 4 [D12.776.624.664.700.110]
        
        Fibroblast Growth Factor 6 [D12.776.624.664.700.112]
        
        fms-Like Tyrosine Kinase 3 [D12.776.624.664.700.114]
        
        Janus Kinase 2 [D12.776.624.664.700.117]
        
        KRIT1 Protein [D12.776.624.664.700.119]
        
        Kruppel-Like Factor 6 [D12.776.624.664.700.120]
        
        Lipocalin-2 [D12.776.624.664.700.123]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.624.664.700.128]
        
        MDS1 and EVI1 Complex Locus Protein [D12.776.624.664.700.129]
        
        MutS Homolog 2 Protein [D12.776.624.664.700.130]
        
        Myeloid-Lymphoid Leukemia Protein [D12.776.624.664.700.148]
        
        N-Myc Proto-Oncogene Protein [D12.776.624.664.700.158]
        
        Pre-B-Cell Leukemia Transcription Factor 1 [D12.776.624.664.700.163]
        
        B-Cell Lymphoma 3 Protein [D12.776.624.664.700.165]
        
        Proto-Oncogene Mas [D12.776.624.664.700.166]
        
        Proto-Oncogene Proteins c-abl [D12.776.624.664.700.167]
        
        Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]
        
        Proto-Oncogene Proteins c-bcl-2 [D12.776.624.664.700.169]
        
        Proto-Oncogene Proteins c-bcl-6 [D12.776.624.664.700.170]
        
        Proto-Oncogene Proteins c-bcr [D12.776.624.664.700.171]
        
        Proto-Oncogene Proteins c-cbl [D12.776.624.664.700.172]
        
        Proto-Oncogene Proteins c-crk [D12.776.624.664.700.174]
        
        Proto-Oncogene Proteins c-ets [D12.776.624.664.700.175]
        
        Proto-Oncogene Proteins c-fes [D12.776.624.664.700.177]
        
        Proto-Oncogene Proteins c-fos [D12.776.624.664.700.179]
        
        Proto-Oncogene Proteins c-fyn [D12.776.624.664.700.180]
        
        Proto-Oncogene Proteins c-hck [D12.776.624.664.700.181]
        
        Proto-Oncogene Proteins c-jun [D12.776.624.664.700.182]
        
        Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]
        
        Proto-Oncogene Proteins c-maf [D12.776.624.664.700.184]
        
        Proto-Oncogene Proteins c-mdm2 [D12.776.624.664.700.185]
        
        Proto-Oncogene Proteins c-met [D12.776.624.664.700.186]
        
        Proto-Oncogene Proteins c-mos [D12.776.624.664.700.187]
        
        Proto-Oncogene Proteins c-myb [D12.776.624.664.700.188]
        
        Proto-Oncogene Proteins c-myc [D12.776.624.664.700.189]
        
        Proto-Oncogene Proteins c-pim-1 [D12.776.624.664.700.191]
        
        Proto-Oncogene Proteins c-rel [D12.776.624.664.700.192]
        
        Proto-Oncogene Proteins c-ret [D12.776.624.664.700.194]
        
        Proto-Oncogene Proteins c-sis [D12.776.624.664.700.195]
        
        Proto-Oncogene Proteins c-vav [D12.776.624.664.700.198]
        
        Proto-Oncogene Proteins c-yes [D12.776.624.664.700.199]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.624.664.700.200]
        
        Proto-Oncogene Proteins pp60(c-src) [D12.776.624.664.700.202]
        
        raf Kinases [D12.776.624.664.700.204]
        
        Receptor, ErbB-2 [D12.776.624.664.700.642]
        
        Receptor, ErbB-3 [D12.776.624.664.700.790]
        
        Receptor, ErbB-4 [D12.776.624.664.700.791]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.624.664.700.792]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
        
        Receptor, Notch4 [D12.776.624.664.700.815]
        
        Receptors, Thyroid Hormone [D12.776.624.664.700.830]
        
        RNA-Binding Protein EWS [D12.776.624.664.700.913]
        
        RNA-Binding Protein FUS [D12.776.624.664.700.915]
        
        RUNX1 Translocation Partner 1 Protein [D12.776.624.664.700.936]
        
        Stathmin [D12.776.624.664.700.957]
        
        T-Cell Acute Lymphocytic Leukemia Protein 1 [D12.776.624.664.700.960]
        
        Wnt-5a Protein [D12.776.624.664.700.962]
        
        Wnt1 Protein [D12.776.624.664.700.967]
        
        Wnt2 Protein [D12.776.624.664.700.978]
        
        Zinc Finger Protein GLI1 [D12.776.624.664.700.989]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nucleoproteins [D12.776.664]
    - RNA-Binding Proteins [D12.776.664.962]
      - Ribonucleoproteins [D12.776.664.962.500]
        
        Heterogeneous-Nuclear Ribonucleoproteins [D12.776.664.962.500.313]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group A-B [D12.776.664.962.500.313.100]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group C [D12.776.664.962.500.313.200]
        
        Heterogeneous-Nuclear Ribonucleoprotein D [D12.776.664.962.500.313.300]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group F-H [D12.776.664.962.500.313.400]
        
        Heterogeneous-Nuclear Ribonucleoprotein K [D12.776.664.962.500.313.500]
        
        Heterogeneous-Nuclear Ribonucleoprotein L [D12.776.664.962.500.313.600]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group M [D12.776.664.962.500.313.700]
        
        Heterogeneous-Nuclear Ribonucleoprotein U [D12.776.664.962.500.313.800]
        
        RNA-Binding Protein EWS [D12.776.664.962.500.313.900]
        
        RNA-Binding Protein FUS [D12.776.664.962.500.313.902]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nucleoproteins [D12.776.664]
    - RNA-Binding Proteins [D12.776.664.962]
      - RNA Recognition Motif Proteins [D12.776.664.962.813]
        
        Heterogeneous-Nuclear Ribonucleoproteins [D12.776.664.962.813.750]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group A-B [D12.776.664.962.813.750.100]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group C [D12.776.664.962.813.750.200]
        
        Heterogeneous-Nuclear Ribonucleoprotein D [D12.776.664.962.813.750.300]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group F-H [D12.776.664.962.813.750.400]
        
        Heterogeneous-Nuclear Ribonucleoprotein K [D12.776.664.962.813.750.500]
        
        Heterogeneous-Nuclear Ribonucleoprotein L [D12.776.664.962.813.750.600]
        
        Heterogeneous-Nuclear Ribonucleoprotein Group M [D12.776.664.962.813.750.700]
        
        Heterogeneous-Nuclear Ribonucleoprotein U [D12.776.664.962.813.750.800]
        
        RNA-Binding Protein EWS [D12.776.664.962.813.750.900]
        
        RNA-Binding Protein FUS [D12.776.664.962.813.750.902]

RNA-Binding Protein EWS Preferred

Concept UI: M0087091
Registry Numbers: 0
Scope Note: A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA.
Terms: RNA-Binding Protein EWS Preferred Term
Term UI T471992
Date12/03/2001
LexicalTag ACX
ThesaurusID NLM (2003); EWSR1 Protein
Term UI T000926432
Date06/08/2017
LexicalTag ABX
ThesaurusID NLM (2018); Ewing Sarcoma Breakpoint Region 1 Protein
Term UI T000926433
Date06/08/2017
LexicalTag NON
ThesaurusID NLM (2018); EWS RNA Binding Protein 1
Term UI T000926431
Date06/08/2017
LexicalTag ABX
ThesaurusID NLM (2018); Ewing Sarcoma Breakpointregion 1 Protein
Term UI T471993
Date12/03/2001
LexicalTag NON
ThesaurusID NLM (2003); EWS Proto-Oncogene Protein
Term UI T478362
Date01/18/2002
LexicalTag ACX
ThesaurusID NLM (2003); EWS Protein
Term UI T117094
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003)

RNA-Binding Protein EWS MeSH Descriptor Data 2025