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Calcineurin MeSH Descriptor Data 2022


MeSH Heading
Calcineurin
Tree Number(s)
D08.811.277.352.650.625.150
D12.644.360.087
D12.776.476.559.150
Unique ID
D019703
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019703
Scope Note
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Entry Term(s)
Calcineurin A
Calcineurin B
Protein Phosphatase 3
Protein Phosphatase 3 Catalytic Subunit
Protein Phosphatase 3 Regulatory Subunit
Protein Phosphatase-2B
Registry Number
EC 3.1.3.16
Previous Indexing
Calcium-Binding Proteins (1986-1997)
Calmodulin-Binding Proteins (1986-1997)
Phosphoprotein Phosphatase (1988-1997)
Public MeSH Note
98; CALCINEURIN was indexed under PHOSPHOPROTEIN PHOSPHATASE 1988-97 & CALMODULIN-BINDING PROTEINS 1986-97; CALCINEURIN B (now CALCINEURIN) was indexed under CALCIUM-BINDING PROTEINS 1994-97
History Note
98; see CALCINEURIN (NM) 1987-97
Entry Combination
antagonists & inhibitors:Calcineurin Inhibitors
Date Established
1998/01/01
Date of Entry
1997/06/20
Revision Date
2021/05/20
Calcineurin Preferred
Calcineurin B Narrower
Calcineurin A Narrower
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