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Protein Phosphatase 2C MeSH Descriptor Data 2022


MeSH Heading
Protein Phosphatase 2C
Tree Number(s)
D08.811.277.352.650.625.716
D12.776.476.559.716
Unique ID
D000071636
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071636
Scope Note
One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.
Entry Term(s)
Magnesium-Dependent Protein Phosphatase 2C beta
PP2C beta
PP2Cepsilon
PP2Cgamma
PPM1 Magnesium-Dependent Protein Phosphatases
PPM1 Protein Phosphatases
PPM1D Phosphatase
PPM1E Phosphatase
PPM1G Phosphatase
Ppm1b Phosphatase
Protein Phosphatase 1D Magnesium-Dependent, delta isoform
Protein Phosphatase 2C beta
Protein Phosphatase 2C delta
Protein Phosphatase 2C epsilon
Protein Phosphatase 2C gamma
Ptc2 Phosphatase
Registry Number
EC 3.1.3.16
Related Numbers
EC 3.1.3.-
EC 3.1.3.16
EC 3.1.3.43
Public MeSH Note
2017; PROTEIN PHOSPHATASE 2C was indexed under PHOSPHOPROTEIN PHOSPHATASES 1993-2016
History Note
2017 (2016)
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2021/05/21
Protein Phosphatase 2C Preferred
Protein Phosphatase 2C epsilon Narrower
Protein Phosphatase 2C beta Narrower
Protein Phosphatase 2C delta Narrower
Protein Phosphatase 2C gamma Narrower
Magnesium-Dependent Protein Phosphatase 2C beta Narrower
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