MeSH Browser

MeSH Heading: Phosphoprotein Phosphatases
Tree Number(s): D08.811.277.352.650.625; D12.776.476.559
Unique ID: D010749
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D010749
Annotation: general; prefer specifics
Scope Note: A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992)
Entry Term(s): Casein Phosphatase; Ecto-Phosphoprotein Phosphatase; Nuclear Protein Phosphatase; Phosphohistone Phosphatase; Phosphoprotein Phosphatase; Phosphoprotein Phosphatase-2C; Phosphoprotein Phosphohydrolase; Phosphoseryl-Protein Phosphatase; Protein Phosphatase; Protein Phosphatase C; Protein Phosphatase C-I; Protein Phosphatase C-II; Protein Phosphatase H-II; Protein Phosphatases; Protein-Serine-Threonine Phosphatase; Protein-Threonine Phosphatase; Serine-Threonine Phosphatase; Threonine Phosphatase
Registry Numbers: EC 3.1.3.16; 0; EC 3.1.3.16; EC 3.1.3.16; EC 3.1.3.16; EC 3.1.3.16
Related Numbers: 9025-75-6; EC 3.1.3.16
CAS Type 1 Name: Phosphoprotein phosphohydrolase
NLM Classification #: QU 136
Previous Indexing: Phosphomonoesterases (1975-1977); Phosphoproteins (1971-1977)
Public MeSH Note: 2008; see PHOSPHOPROTEIN PHOSPHATASE 1994-2007; see PHOSPHOPROTEIN PHOSPHATASES & PHOSPHOPROTEIN PHOSPHOHYDROLASES 1978-1993; PROTEIN-SERINE-THREONINE PHOSPHATASE was indexed under PHOSPHOPROTEIN PHOSPHATASES 1991-2007
History Note: 2008(1994)
Date Established: 1978/01/01
Date of Entry: 1977/04/15
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Monoester Hydrolases [D08.811.277.352.650]
        
        Acid Phosphatase [D08.811.277.352.650.025]
        
        ADP-Ribose 1''-Phosphate Phosphatases [D08.811.277.352.650.030]
        
        Alkaline Phosphatase [D08.811.277.352.650.035]
        
        Fructose-Bisphosphatase [D08.811.277.352.650.200]
        
        Glucose-6-Phosphatase [D08.811.277.352.650.225]
        
        Histidinol-Phosphatase [D08.811.277.352.650.300]
        
        4-Nitrophenylphosphatase [D08.811.277.352.650.575]
        
        Mitogen-Activated Protein Kinase Phosphatases [D08.811.277.352.650.587]
        
        Nucleotidases [D08.811.277.352.650.600]
        
        Phosphatidate Phosphatase [D08.811.277.352.650.620]
        
        Phosphofructokinase-2 [D08.811.277.352.650.622]
        
        Phosphoinositide Phosphatases [D08.811.277.352.650.624]
        
        Phosphoprotein Phosphatases [D08.811.277.352.650.625]
        
        Calcineurin [D08.811.277.352.650.625.150]
        
        Dual-Specificity Phosphatases [D08.811.277.352.650.625.225]
        
        Glycogen-Synthase-D Phosphatase [D08.811.277.352.650.625.300]
        
        Myosin-Light-Chain Phosphatase [D08.811.277.352.650.625.475]
        
        Phosphorylase Phosphatase [D08.811.277.352.650.625.650]
        
        Protein Phosphatase 1 [D08.811.277.352.650.625.687]
        
        Protein Phosphatase 2 [D08.811.277.352.650.625.706]
        
        Protein Phosphatase 2C [D08.811.277.352.650.625.716]
        
        Pyruvate Dehydrogenase (Lipoamide)-Phosphatase [D08.811.277.352.650.625.725]
        
        Tartrate-Resistant Acid Phosphatase [D08.811.277.352.650.625.862]
        
        6-Phytase [D08.811.277.352.650.700]
        
        Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
        
        PTEN Phosphohydrolase [D08.811.277.352.650.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]

Phosphoprotein Phosphatases Preferred

Concept UI: M0016695
Registry Numbers: EC 3.1.3.16
Related Numbers: 9025-75-6; EC 3.1.3.16
Scope Note: A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. (Enzyme Nomenclature, 1992)
Terms: Phosphoprotein Phosphatases Preferred Term
Term UI T031758
Date12/02/1992
LexicalTag NON
ThesaurusID NLM (1994); Phosphoprotein Phosphatase
Term UI T031759
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); Protein Phosphatase
Term UI T000999791
Date11/29/2019
LexicalTag NON
ThesaurusID NLM (2021); Protein Phosphatases
Term UI T031764
Date03/29/1977
LexicalTag NON
ThesaurusID UNK (19XX); Serine-Threonine Phosphatase
Term UI T212733
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Protein-Serine-Threonine Phosphatase
Term UI T212735
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Phosphoprotein Phosphohydrolase
Term UI T031760
Date11/20/1992
LexicalTag NON
ThesaurusID NLM (1994)

Ecto-Phosphoprotein Phosphatase Narrower

Nuclear Protein Phosphatase Narrower

Phosphohistone Phosphatase Narrower

Phosphoseryl-Protein Phosphatase Narrower

Protein Phosphatase C-I Narrower

Protein Phosphatase C-II Narrower

Protein Phosphatase H-II Narrower

Protein-Threonine Phosphatase Narrower

Phosphoprotein Phosphatase-2C Narrower

Casein Phosphatase Narrower

Protein Phosphatase C Narrower

Phosphoprotein Phosphatases MeSH Descriptor Data 2025