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Phosphofructokinase-2 MeSH Descriptor Data 2023


MeSH Heading
Phosphofructokinase-2
Tree Number(s)
D08.811.277.352.650.622
D08.811.641.843
D08.811.913.696.620.225.850.750
Unique ID
D025481
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D025481
Scope Note
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
Entry Term(s)
6-PF-2-K-Fru-2,6-P(2)ase
6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase
6-Phosphofructo-2-kinase
6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase
6PF2K
ATP-D-Fructose-6-phosphate 2-phosphotransferase
F Kinase-F-bisphosphatase
Fru-6-P,2-kinase
Fru-kinase-Fru-bisphosphatase
Fructose 2,6-bisphosphatase
Fructose-2,6-bisphosphatase
Fructose-2,6-bisphosphate 2-phosphatase
Fructose-6-P,2-kinase
Fructose-6-phosphate,2-kinase
Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase
fructose-2,6-diphosphatase
Registry Number
EC 2.7.1.105
Related Numbers
EC 3.1.3.46
Previous Indexing
Phosphofructokinase-1 (1981-2001)
Phosphoric Monoester Hydrolases (1983-2001)
Phosphotransferases (1981-2001)
See Also
Phosphofructokinase-1
Public MeSH Note
2002; 6-PHOSPHOFRUCTO-2-KINASE was indexed under PHOSPHOTRANSFERASES (NM) 1993-2001, under PHOSPHOTRANSFERASES, ATP (NM) 1981-1993; FRUCTOSE-2,6-BISPHOSPATASE was indexed under PHOSPHORIC MONOESTER HYDROLASES (NM) 1983-2001; 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE was indexed under FRUCTOSE-BISPHOSPHATASE (NM) 1990-2001, under MULTIENZYME COMPLEXES (NM) 1990-2001, under PHOSPHOFRUCTOKINASE-1 (NM) 1990-2001
History Note
2002; for 6-PHOSPHOFRUCTO-2-KINASE use PHOSPHOTRANSFERASES (NM) 1993-2001, use PHOSPHOTRANSFERASES, ATP (NM) 1981-1993; for FRUCTOSE-2,6-BISPHOSPATASE use PHOSPHORIC MONOESTER HYDROLASES (NM) 1983-2001; for 6-PHOSPHOFRUCTO-2-KINASE-FRUCTOSE-2,6-BISPHOSPHATASE use FRUCTOSE-BISPHOSPHATASE (NM) 1990-2001, use MULTIENZYME COMPLEXES (NM) 1990-2001, use PHOSPHOFRUCTOKINASE-1 (NM) 1990-2001
Date Established
2002/01/01
Date of Entry
2001/07/25
Revision Date
2013/07/08
Phosphofructokinase-2 Preferred
Fructose-2,6-bisphosphatase Narrower
6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase Broader
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