MeSH Browser

MeSH Heading: Phosphofructokinase-1
Tree Number(s): D08.811.913.696.620.225.850.500
Unique ID: D010732
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D010732
Annotation: general or unspecified; prefer specifics
Scope Note: An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.
Entry Term(s): 6-Phosphofructo-1-kinase; 6-Phosphofructokinase; Fructose-6-P 1-Kinase; Fructose-6-phosphate 1-Phosphotransferase
Registry Numbers: EC 2.7.1.11
Related Numbers: 9001-80-3
CAS Type 1 Name: ATP:D-fructose-6-phosphate 1-phosphotransferase
See Also: Glycogen Storage Disease Type VII; Phosphofructokinase-2
Public MeSH Note: 2002; see 6-PHOSPHOFRUCTOKINASE 1993-2001, see PHOSPHOFRUCTOKINASE 1965-1992
History Note: 2002
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2009/07/13

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0016667
Registry Numbers: EC 2.7.1.11
Related Numbers: 9001-80-3
Scope Note: An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.
Terms: Phosphofructokinase-1 Preferred Term
Term UI T430187
Date12/04/2000
LexicalTag NON
ThesaurusID NLM (2002); 6-Phosphofructo-1-kinase
Term UI T031705
Date01/17/1990
LexicalTag NON
ThesaurusID NLM (1991); 6-Phosphofructokinase
Term UI T031706
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1993); Fructose-6-P 1-Kinase
Term UI T031703
Date10/20/1983
LexicalTag NON
ThesaurusID UNK (19XX); Fructose-6-phosphate 1-Phosphotransferase
Term UI T031704
Date08/18/1980
LexicalTag NON
ThesaurusID UNK (19XX)

Phosphofructokinase-1 MeSH Descriptor Data 2024