MeSH Browser

MeSH Heading: Core Binding Factor Alpha 2 Subunit
Tree Number(s): D12.776.930.155.200.200
Unique ID: D050676
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050676
Scope Note: A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
Entry Term(s): AML1A Protein; AML1B Protein; AML1C Protein; AML1D Protein; Acute Myeloid Leukemia 1 Protein; Acute Myeloid Leukemia 1A Protein; Acute Myeloid Leukemia 1B Protein; Acute Myeloid Leukemia 1C Protein; Acute Myeloid Leukemia 1D Protein; Core-Binding Factor Alpha 2 Protein; Pebp2a2 Protein; Runt-Related Transcription Factor 1; Runx1 Protein
Previous Indexing: DNA-Binding Proteins (1996-2005); Neoplasm Proteins (1993-1996); Proto-Oncogene Proteins (1996-2005); Transcription Factors (1996-2005)
Public MeSH Note: 2006; RUNX1 PROTEIN was indexed under DNA-BINDING PROTEINS 1996-2005, NEOPLASM PROTEINS 1993-1996, PROTO-ONCOGENE PROTEINS 1996-2005, & TRANSCRIPTION FACTORS 1996-2005
History Note: 2006(1993)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2017/06/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0215816
Scope Note: A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.
Terms: Core Binding Factor Alpha 2 Subunit Preferred Term
Term UI T575929
Date03/08/2004
LexicalTag NON
ThesaurusID NLM (2006); Acute Myeloid Leukemia 1 Protein
Term UI T575927
Date03/08/2004
LexicalTag NON
ThesaurusID NLM (2006); Core-Binding Factor Alpha 2 Protein
Term UI T622158
Date12/06/2004
LexicalTag NON
ThesaurusID NLM (2006); Pebp2a2 Protein
Term UI T622159
Date12/06/2004
LexicalTag ABX
ThesaurusID NLM (2006); Runt-Related Transcription Factor 1
Term UI T575928
Date03/08/2004
LexicalTag NON
ThesaurusID NLM (2006); Runx1 Protein
Term UI T575096
Date03/02/2004
LexicalTag ABX
ThesaurusID NLM (2006)

Core Binding Factor Alpha 2 Subunit MeSH Descriptor Data 2024