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Fusion Proteins, bcr-abl MeSH Descriptor Data 2023


MeSH Heading
Fusion Proteins, bcr-abl
Tree Number(s)
D08.811.913.696.620.682.725.500.500
D12.776.476.568.500.500
D12.776.602.500.500.100
D12.776.624.664.500.100
D12.776.624.664.700.171.500
Unique ID
D016044
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016044
Scope Note
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Entry Term(s)
Bcr-Abl Tyrosine Kinase
Oncogene Protein p185(bcr-abl)
Oncogene Protein p190(bcr-abl)
Oncogene Protein p210(bcr-abl)
Oncogene Protein p230(bcr-abl)
bcr-abl Fusion Protein
bcr-abl Fusion Proteins
p185(bcr-abl) Fusion Proteins
p190(bcr-abl) Fusion Proteins
p210(bcr-abl) Fusion Proteins
p230(bcr-abl) Fusion Proteins
Registry Number
EC 2.7.10.2
Previous Indexing
Neoplasm Proteins (1986-1989)
See Also
Philadelphia Chromosome
Public MeSH Note
91; was BCR-ABL FUSION PROTEINS 1990
Online Note
use FUSION PROTEINS, BCR-ABL to search BCR-ABL FUSION PROTEINS 1990
History Note
91; was BCR-ABL FUSION PROTEINS 1990
Date Established
1990/01/01
Date of Entry
1989/05/25
Revision Date
2021/06/30
Fusion Proteins, bcr-abl Preferred
Oncogene Protein p190(bcr-abl) Narrower
Oncogene Protein p230(bcr-abl) Narrower
Oncogene Protein p185(bcr-abl) Narrower
Oncogene Protein p210(bcr-abl) Narrower
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