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MAP Kinase Kinase 4 MeSH Descriptor Data 2022


MeSH Heading
MAP Kinase Kinase 4
Tree Number(s)
D08.811.913.696.620.682.700.565.400
D08.811.913.696.620.682.725.200.400
D12.776.476.563.565.400
D12.776.476.568.200.400
Unique ID
D048670
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D048670
Scope Note
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.
Entry Term(s)
JN Kinase Kinase
JNK Kinase
JNK-Activating Protein Kinase
JNKK1 Protein Kinase
Jun Amino-Terminal Kinase Kinase
MEK4 Protein Kinase
Mitogen-Activated Protein Kinase Kinase 4
SAP Kinase Kinase 1
SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1
SAPK-ERK Kinase 1
SEK1 Protein Kinase
Stress-Activated Protein Kinase Kinase 1
Registry Number
EC 2.7.12.2
Previous Indexing
Mitogen-Activated Protein Kinases (2000-2004)
Protein-Serine-Threonine Kinases (1995-1999)
Protein-Tyrosine Kinase (2000-2004)
Public MeSH Note
2005; MAP KINASE KINASE 4 was indexed under MITOGEN-ACTIVATED PROTEIN KINASES & PROTEIN-TYROSINE KINASE 2000-2004, & under PROTEIN-SERINE-THREONINE KINASES 1995-1999; JNK-ACTIVATING PROTEIN KINASE was indexed under JNK MITOGEN-ACTIVATED PROTEIN KINASES 2004-2005; under MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASES 2000-2005, & under PROTEIN KINASES 1995-1999
History Note
2005(1995)
Date Established
2005/01/01
Date of Entry
2004/07/07
Revision Date
2021/05/21
MAP Kinase Kinase 4 Preferred
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