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DCC Receptor MeSH Descriptor Data 2022


MeSH Heading
DCC Receptor
Tree Number(s)
D12.644.360.075.413
D12.776.476.075.413
D12.776.543.750.003.500
D12.776.624.776.021
Unique ID
D000075389
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000075389
Scope Note
A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.
Entry Term(s)
DCC Tumor Suppressor Protein
DCC-Netrin-1 Receptor
Deleted in Colorectal Carcinoma Protein
Registry Number
0
Previous Indexing
Receptors, Cell Surface (2005-2017)
Tumor Suppressor Proteins (2005-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/05/24
DCC Receptor Preferred
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