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Fanconi Anemia Complementation Group N Protein MeSH Descriptor Data 2025


MeSH Heading
Fanconi Anemia Complementation Group N Protein
Tree Number(s)
D12.776.313.953
D12.776.624.776.051
D12.776.660.323
Unique ID
D000076164
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076164
Scope Note
A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.
Entry Term(s)
FANCN Protein
PALB2 Protein
Partner and Localizer of BRCA2 Protein
Registry Numbers
0
Previous Indexing
Nuclear Proteins (2006-2017)
Tumor Suppressor Proteins (2006-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/29
Fanconi Anemia Complementation Group N Protein Preferred
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