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Silent Information Regulator Proteins, Saccharomyces cerevisiae MeSH Descriptor Data 2022


MeSH Heading
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Tree Number(s)
D12.776.354.750.750
D12.776.660.820
Unique ID
D038281
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D038281
Scope Note
A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.
Entry Version
SILENT INFORMATION REGULAT PROTEINS SACCH CEREV
Entry Term(s)
SIR Proteins, S cerevisiae
Silent Information Regulator Proteins, S cerevisiae
Silent Mating Type Information Regulator Protein, S cerevisiae
Registry Number
0
See Also
Sirtuins
Public MeSH Note
2003
History Note
2003
Date Established
2003/01/01
Date of Entry
2002/07/03
Revision Date
2005/06/30
Silent Information Regulator Proteins, Saccharomyces cerevisiae Preferred
Silent Mating Type Information Regulator Protein, S cerevisiae Narrower
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