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Protamines MeSH Descriptor Data 2023


MeSH Heading
Protamines
Tree Number(s)
D12.776.660.750
D12.776.664.750
Unique ID
D011479
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011479
Annotation
heparin antag
Scope Note
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
Entry Term(s)
Protamine
Protamine Chloride
Protamine Sulfate
Pharm Action
Heparin Antagonists
Registry Number
0
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2020/05/27
Protamines Preferred
Protamine Sulfate Narrower
Protamine Chloride Narrower
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