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Deubiquitinating Enzyme CYLD MeSH Descriptor Data 2022


MeSH Heading
Deubiquitinating Enzyme CYLD
Tree Number(s)
D08.811.037.375
D12.776.624.776.482
Unique ID
D000074749
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074749
Scope Note
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
Entry Term(s)
CYLD Protein
Cylindromatosis Protein
Deubiquitinating Enzyme Cylindromatosis
Registry Number
EC 3.4.19.12
Previous Indexing
Tumor Suppressor Proteins (2001-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/02
Deubiquitinating Enzyme CYLD Preferred
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