MeSH Browser

MeSH Heading: Deubiquitinating Enzyme CYLD
Tree Number(s): D08.811.037.375; D12.776.624.776.482
Unique ID: D000074749
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074749
Scope Note: A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
Entry Term(s): CYLD Protein; Cylindromatosis Protein; Deubiquitinating Enzyme Cylindromatosis
Registry Number: EC 3.4.19.12
Previous Indexing: Tumor Suppressor Proteins (2001-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000627388
Registry Number: EC 3.4.19.12
Scope Note: A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.
Terms: Deubiquitinating Enzyme CYLD Preferred Term
Term UI T000916956
Date03/08/2017
LexicalTag ABX
ThesaurusID NLM (2018); Cylindromatosis Protein
Term UI T000919289
Date03/17/2017
LexicalTag NON
ThesaurusID NLM (2018); Deubiquitinating Enzyme Cylindromatosis
Term UI T000919290
Date03/17/2017
LexicalTag NON
ThesaurusID NLM (2018); CYLD Protein
Term UI T000916957
Date03/08/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Deubiquitinating Enzyme CYLD MeSH Descriptor Data 2024