Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Von Hippel-Lindau Tumor Suppressor Protein MeSH Descriptor Data 2025


MeSH Heading
Von Hippel-Lindau Tumor Suppressor Protein
Tree Number(s)
D08.811.464.938.750.875
D12.776.624.776.865
Unique ID
D051794
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051794
Scope Note
A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.
Entry Term(s)
VHL Tumor Suppressor Protein
Registry Numbers
EC 2.3.2.27
Public MeSH Note
2006; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN was indexed under TUMOR SUPPRESSOR PROTEINS 2002-2005, under UBIQUITIN-PROTEIN LIGASES 2004-2005, under LIGASES 2002-3003, under PROTEINS 1995-2001, & under NUCLEAR PROTEINS 1995
History Note
2006 (1995)
Entry Combination
deficiency:von Hippel-Lindau Disease
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2016/06/02
Von Hippel-Lindau Tumor Suppressor Protein Preferred
page delivered in 0.133s