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Nedd4 Ubiquitin Protein Ligases MeSH Descriptor Data 2022


MeSH Heading
Nedd4 Ubiquitin Protein Ligases
Tree Number(s)
D05.500.199.500
D08.811.464.938.750.257
D12.776.543.990.493.500
Unique ID
D000075702
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000075702
Scope Note
E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
Entry Term(s)
Nedd4 Proteins
Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
Registry Number
EC 2.3.2.26
Public MeSH Note
2018; NEDD4 UBIQUITIN PROTEIN LIGASES was indexed under UBIQUITIN-PROTEIN LIGASES and ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT 2005-2017; under LIGASES 1996-2004; and under CALCIUM-BINDING PROTEINS 1996-2003
History Note
2018 (1996)
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/29
Nedd4 Ubiquitin Protein Ligases Preferred
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