- Concept UI
- M0028676
- Registry Numbers
- EC 1.6.3.-
- Scope Note
- A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
- Terms
-
NADPH Oxidases
Preferred Term
Term UI
T000916870
Date03/07/2017
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
Nox Proteins
Term UI
T000920963
Date04/05/2017
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
NAD(P)H Oxidases
Term UI
T000916871
Date03/07/2017
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
NADPH Oxidase
Term UI
T057367
Date01/01/1999
LexicalTag
ACX
ThesaurusID
NLM (1997)
-
NAD(P)H oxidase
Term UI
T407268
Date02/16/2000
LexicalTag
ACX
ThesaurusID
NLM (2006)