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DNA (Cytosine-5-)-Methyltransferase 1 MeSH Descriptor Data 2022


MeSH Heading
DNA (Cytosine-5-)-Methyltransferase 1
Tree Number(s)
D08.811.913.555.500.350.100.500.500
D12.776.157.687.313
D12.776.660.720.313
Unique ID
D000076123
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076123
Scope Note
A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.
Entry Term(s)
DNMT1 Enzyme
Registry Number
EC 2.1.1.37
See Also
Zinc Fingers
Public MeSH Note
2018; DNA (CYTOSINE-5-)-METHYLTRASFERASE 1 was indexed under DNA (CYTOSINE-5-)-METHYLTRASFERASES 1999-2017
History Note
2018 (1999)
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/29
DNA (Cytosine-5-)-Methyltransferase 1 Preferred
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