MeSH Browser

MeSH Heading: PHD Zinc Fingers
Tree Number(s): G02.111.570.820.709.275.500.985.438
Unique ID: D000075925
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075925
Scope Note: Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur in many proteins that function in chromatin-mediated gene expression and EPIGENETICS such as POLYCOMB-GROUP PROTEINS.
Entry Term(s): PHD Domains; PHD Finger Domain; PHD Fingers; PHD Motif; PHD Motifs; PHD Zinc Finger
Previous Indexing: Amino Acid Sequence (1995-2017); Molecular Sequence Data (1995-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M000631685
Scope Note: Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur in many proteins that function in chromatin-mediated gene expression and EPIGENETICS such as POLYCOMB-GROUP PROTEINS.
Terms: PHD Zinc Fingers Preferred Term
Term UI T000924516
Date05/15/2017
LexicalTag ABX
ThesaurusID NLM (2018); PHD Fingers
Term UI T000924517
Date05/15/2017
LexicalTag ABX
ThesaurusID NLM (2018); PHD Motifs
Term UI T000924520
Date05/15/2017
LexicalTag ABX
ThesaurusID NLM (2018); PHD Domains
Term UI T000924519
Date05/15/2017
LexicalTag ABX
ThesaurusID NLM (2018); PHD Zinc Finger
Term UI T000924515
Date05/15/2017
LexicalTag NON
ThesaurusID NLM (2018); PHD Finger Domain
Term UI T000924521
Date05/15/2017
LexicalTag ABX
ThesaurusID NLM (2018); PHD Motif
Term UI T000924518
Date05/15/2017
LexicalTag ABX
ThesaurusID NLM (2018)

PHD Zinc Fingers MeSH Descriptor Data 2024